Mitochondrial regulation of bone homeostasis via mitochondria transfer [RNA-seq]
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorptionNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE225414_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA935661 and SRA study SRP422913. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7048184 BMMs_1 BMMs
- GSM7048185 BMMs_2 BMMs
- GSM7048186 BMMs_3 BMMs
- GSM7048187 BMMs_Mito_1 BMMs_Mito
- GSM7048188 BMMs_Mito_2 BMMs_Mito
- GSM7048189 BMMs_Mito_3 BMMs_Mito
- GSM7048190 OCPs_1 OCPs
- GSM7048191 OCPs_2 OCPs
- GSM7048192 OCPs_3 OCPs
- GSM7048193 OCPs_Mito_1 OCPs_Mito
- GSM7048194 OCPs_Mito_2 OCPs_Mito
- GSM7048195 OCPs_Mito_3 OCPs_Mito
- GSM7048196 mOCs_1 mOCs
- GSM7048197 mOCs_2 mOCs
- GSM7048198 mOCs_3 mOCs
- GSM7048199 mOCs_Mito_1 mOCs_Mito
- GSM7048200 mOCs_Mito_2 mOCs_Mito
- GSM7048201 mOCs_Mito_3 mOCs_Mito
- GSE328769 Alzheimer's disease associated Presenilin 2 N141I mutation impairs neuronal lipid homeostasis and mitochondrial dynamics through selective downregulation of the Golgi exchange factor Gbf1 16 samples shares mitochondrial, mitochondria, homeostasis
- GSE273310 DELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq] 64 samples shares mitochondrial, mitochondria, rna-seq
- GSE326291 Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [RNA-seq} 36 samples shares mitochondrial, mitochondria, rna-seq
- GSE279117 HIF1α deletion promotes mitochondrial repurposing in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages 24 samples shares mitochondrial, mitochondria, bone
- GSE312828 Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution. [RNA-Seq] 24 samples shares mitochondrial, mitochondria, rna-seq
- GSE306116 Caspase-3 Control of RNA Splicing and Mitochondrial Dynamics in Microglia during Parkinson’s Disease [RNA-Seq] 12 samples shares mitochondrial, mitochondria, rna-seq
- GSE327604 Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis [RNA-Seq] 12 samples shares mitochondrial, mitochondria, rna-seq
- GSE295742 Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity 12 samples shares mitochondrial, mitochondria, transfer
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.