← BioTransfer GEO Dataset Finder
GEO series

Effect of p53 knockout on gene expression during capmatinib treatment of NF1-MET murine MPNST cells

GSE225747 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/03/14 Platform GPL24247
Summary
To investigate the function of p53 in regulating response to MET inhibition in MPNST cells we established NF1-MET;sgP53 cells in which Trp53 was knocked out using CRISPR-Cas9. As a control, the parental NF1-MET was transduced with CRISPR-Cas9 in the absence of sgRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of the 2 different cells treated with either capmatinib or vehicle in duplicate.
Published in
p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs
Grit JL, McGee LE, Tovar EA et al. · Oncogene 2024 · PMID 38480916 · doi:10.1038/s41388-024-03000-9
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE225747_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA932754 and SRA study SRP421493. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.