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RNA sequencing of aortic tissues from Prdm16 smooth muscle-specific KO and control mice

GSE227692 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/03 Platform GPL24247
Summary
To explore the function of Prdm16 gene in vascular smooth muscle cells (VSMCs) in vivo, we generated Prdm16 SMC-specific KO mouse model using tamoxifen-inducible Myh11-CreERT2 Cre-driver. We performed bulk RNA-sequencing on aortic tissues of both Prdm16 SMC-specific KO and control mice. Differential analysis revealed ablation of Prdm16 in SMCs disrupted the global transcriptome profile of aortic tissues. Expression of a list of genes implicated in cardiovascular disease development and SMC phenotypic modulation are significantly altered following deletion of Prdm16. We propose these transcriptome changes following loss of Prdm16 likely predispose the VSMC to a disease state.
Published in
Coronary artery disease risk gene PRDM16 regulates smooth muscle homeostasis
Dong K, Zuo Y, Yao Y et al. · Journal of molecular and cellular cardiology 2026 · PMID 41667033 · doi:10.1016/j.yjmcc.2026.02.002
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Also filed as BioProject PRJNA946662 and SRA study SRP428243. Searching any of these in the dataset finder brings you back here.

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