CRISPR-Cas9 base editing to render CaMKIIδ phosphoresistant improves survival and cardiac function in heart failure
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × WT-sTAC vs 3 × WT-Sham vs 3 × T287A-sTAC vs 3 × T287A-ShamGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE227720_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA946711 and SRA study SRP428245. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7106055 WT-sTAC_1 WT-sTAC
- GSM7106056 WT-sTAC_2 WT-sTAC
- GSM7106057 WT-sTAC_3 WT-sTAC
- GSM7106058 WT-Sham_1 WT-Sham
- GSM7106059 WT-Sham_2 WT-Sham
- GSM7106060 WT-Sham_3 WT-Sham
- GSM7106061 T287A-sTAC_1 T287A-sTAC
- GSM7106062 T287A-sTAC_2 T287A-sTAC
- GSM7106063 T287A-sTAC_3 T287A-sTAC
- GSM7106065 T287A-Sham_1 T287A-Sham
- GSM7106068 T287A-Sham_2 T287A-Sham
- GSM7106071 T287A-Sham_3 T287A-Sham
- GSE280699 The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age [RNA-seq] 78 samples shares improves, cardiac
- GSE271798 NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich’s Ataxia 50 samples shares survival, cardiac
- GSE283273 Urolithin A Provides Cardioprotection and Mitochondrial Quality Enhancement Preclinically and Improves Cardiovascular Health Biomarkers in Humans [mouse_cardiac_aging] 18 samples shares improves, cardiac
- GSE250165 PD1 blockade improves survival and CD8+ cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice 14 samples shares improves, survival
- GSE310954 Remodeling of Suppressive Melanoma Microenvironments by Particle-Mediated Modulation of the STING/IL-6/PD-L1 Axis Improves Tumor Immunity and Survival 11 samples shares improves, survival
- GSE246524 In Vivo Direct Reprogramming by AAV Improves Cardiac Function after Myocardial Infarction. [RNA-seq] 10 samples shares improves, cardiac
- GSE198735 Cardiac resident macrophage-derived legumain improves cardiac repair via promoting clearance and degradation of apoptotic cardiomyocytes after myocardial infarction 6 samples shares improves, cardiac
- GSE300428 Rbm24 promotes outer hair cell survival through Insm1 repression while independently regulating hair bundle morphogenesis 163 samples shares survival
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.