GEO series
CRISPR-Cas9 base editing to render CaMKIIδ phosphoresistant improves survival and cardiac function in heart failure
GSE227720
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/07/22
GPL19057
Summary
We ablated the autophosphorylation site of CaMKIIδ (T287) using CRISPR-Cas9 adenine base editing technology. Ten-weeks old C57Bl6 wildtype and CaMKIIδ T287A mice were subjected to either sham or severe transverse aortic constriction (sTAC) surgery (WT-Sham, WT-sTAC, T287A-Sham, T287A-sTAC; 3 biological replicates per group). Two weeks after the surgery, hearts were harvested for RNA isolation and subsequent bulk RNA sequencing and gene expression profiling analysis.
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