m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway
DNA methylation · mouse · 36 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Mus musculus (mouse)
- Samples
- 36 samples: 30 distinct titles, 6 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE100048_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA391347 and SRA study SRP110047. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 36 sample titles: 30 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM2676989 Mett3_Naive_KO1_004
- GSM2676990 Mett3_Naive_KO2_005
- GSM2676991 Mett3_Naive_WT3_006
- GSM2676992 Mett3_Naive_WT4_012
- GSM2676993 Input WT 0 min IL-7
- GSM2676994 Input WT 15min IL-7
- GSM2676995 Input WT 30min IL-7
- GSM2676996 Input WT 45min IL-7
- GSM2676997 Input WT 60min IL-7
- GSM2676998 Input WT 75min IL-7
- GSM2676999 Input KO 0min IL-7
- GSM2677000 Input KO 15min IL-7
- GSM2677001 Input KO 30min IL-7
- GSM2677002 Input KO 60min IL-7
- GSM2677003 Enriched WT 0min IL-7
- GSM2677004 Enriched WT 15min IL-7
- GSM2677005 Enriched WT 30min IL-7
- GSM2677006 Enriched WT 45min IL-7
- GSM2677007 Enriched WT 60min IL-7
- GSM2677008 Enriched WT 75min IL-7
- GSM2677009 Enriched KO 0min IL-7
- GSM2677010 Enriched KO 15min IL-7
- GSM2677011 Enriched KO 30min IL-7
- GSM2677012 Enriched KO 60min IL-7
- GSM2678049 Ribosome Profiling Input for WT, rep1
- GSM2678050 Ribosome Profiling Input for WT, rep2
- GSM2678051 Ribosome Profiling Input for KO, rep1
- GSM2678052 Ribosome Profiling Input for KO, rep2
- GSM2678053 WT Ribosome Profiling, rep1
- GSM2678054 WT Ribosome Profiling, rep2
- GSM2678055 KO Ribosome Profiling, rep1
- GSM2678056 KO Ribosome Profiling, rep2
- GSM2678057 WT Input, rep1
- GSM2678058 WT Input, rep2
- GSM2678059 WT RIP, rep1
- GSM2678060 WT RIP, rep2
- GSE300419 Photobiomodulation mitigates LPS-induced astrocyte neuroinflammation via the STAT5A/SOCS3 axis 32 samples shares stat5, socs
- GSE272913 Dnmt3a Controls Hematopoietic Stem Cells via DNA Methylation-Independent Regulation of Telomeres 66 samples shares methylation, controls
- GSE61995 m6A mRNA Methylation Facilitates Resolution of Naïve Pluripotency Towards Differentiation (m6a-seq) 18 samples shares methylation, mrna
- GSE253726 Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis 12 samples shares methylation, homeostasis
- GSE228457 IL-7 mediated immunoregulatory feedback loop promotes dampening of immune effector functions by hypoinflammatory monocytes. 305 samples shares il-7
- GSE228456 Cell-intrinsic effect of IL-7R signaling of monocytes within C57BL/6J mouse ears infected with Leishmania major [bulk RNA-seq] 87 samples shares il-7
- GSE277696 Role of endothelial SOCS3 in the transcriptional response to LPS 45 samples shares socs
- GSE310017 Disease-associated mutations on the STAT5B SH2 domain regulate cholesterol and lipid metabolism in liver [RNA-Seq liver] 37 samples shares stat5
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.