Pathogenic mechanism and therapeutic intervention of impaired N7-methylguanosine (m7G) tRNA modification [RNC seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Input_WT vs 3 × Input_Homo vs 3 × RNC_WT vs 3 × RNC_HomoGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE229240_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA953621 and SRA study SRP431600. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7157547 Input_WT1 Input_WT
- GSM7157548 Input_WT2 Input_WT
- GSM7157549 Input_WT3 Input_WT
- GSM7157550 Input_Homo1 Input_Homo
- GSM7157551 Input_Homo2 Input_Homo
- GSM7157552 Input_Homo3 Input_Homo
- GSM7157553 RNC_WT1 RNC_WT
- GSM7157554 RNC_WT2 RNC_WT
- GSM7157555 RNC_WT3 RNC_WT
- GSM7157556 RNC_Homo1 RNC_Homo
- GSM7157557 RNC_Homo2 RNC_Homo
- GSM7157558 RNC_Homo3 RNC_Homo
- GSE229612 Pathogenic mechanism and therapeutic intervention of impaired N7-methylguanosine (m7G) tRNA modification 24 samples shares n7-methylguanosine, intervention, modification, therapeutic, pathogenic, impaired, trna
- GSE249534 Rosmarinic acid alleviates radiation-induced pulmonary fibrosis by downregulating tRNA N7-Methylguanosine modification-regulated fibroblast to myofibroblast transition through the exosomes pathway 12 samples shares n7-methylguanosine, modification, trna
- GSE305529 METTL3-Driven RNA Modifications: A Key Mechanism and Potential Therapeutic Target in Pancreatic Acinar Cell Carcinoma in Mice [MeRIP] 48 samples shares modification, therapeutic
- GSE250593 mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery 46 samples shares modification, trna
- GSE308116 Epigenetic modification, as a distinctive therapeutic molecule for Parkinson’s disease gene therapy. 17 samples shares modification, therapeutic
- GSE286704 t6A tRNA modification defines RIG-I mediated anti-tumour [Ribo-seq] immune response 12 samples shares modification, trna
- GSE239608 tRNA m1A modification enhances anti-tumor immunity in macrophages by promoting translation of key interferon associated genes 12 samples shares modification, trna
- GSE275602 tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells 12 samples shares modification, trna
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.