GEO series
Transcriptomic analysis of high-fat diet-fed mice treated with CYP4A inhibitors
GSE229697
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/11/06
GPL21626
Summary
Cytochrome P4504A (CYP4A) is known to be related to the development of type 2 diabetes (T2DM) and non-alcoholic fatty liver disease (NAFLD). We discovered selective CYP4A inhibitors, C481 (C1) and C482 (C2), and confirmed the therapeutic effects of these inhibitors on T2DM and NAFLD. In order to confirm the mechanisms of C1 and C2, inhibitors were treated in high-fat diet (HFD)-fed mice and RNA sequencing was performed using the liver tissues.
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Paper (PMID 39367660) ↗
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