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Transcriptome data of bone marrow hematopoietic stem cells (HSCs) with IGF-1 treatment

GSE229985 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/05 Platform GPL24247
Summary
Insulin-like growth factor-1 (IGF-1) is known as a hematopoietic factor which impacts hematopoietic reconstitution and facilitates thrombopoiesis, although its direct effect on hematopoietic stem cells (HSCs) remains unclear. Here, we show that IGF-1 rapidly prompts megakaryocyte (Mk)-lineage differentiation of HSCs by enhancing mitochondrial activity in HSCs. To identify the phenotype switching and function variation in HSCs with IGF-1 treatment, we performed RNA-seq of HSCs from the bone marrow of mice with single-dose IGF-1 treatment (IGF-1) and their age-matched control mice (Ctrl).
Published in
Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury
Liao W, Chen X, Zhang S et al. · Cell communication and signaling : CCS 2024 · PMID 38802843 · doi:10.1186/s12964-024-01651-5
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Also filed as BioProject PRJNA956926 and SRA study SRP433288. Searching any of these in the dataset finder brings you back here.

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