ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer [ATAC-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × sgNT vs 3 × sgNTDHT vs 3 × sgZNF397 vs 3 × sgZNF397DHTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate CancerCancer discovery · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE260467_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1081833 and SRA study SRP492332. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8117811 sgNT-1 sgNT
- GSM8117812 sgNT-2 sgNT
- GSM8117813 sgNT-3 sgNT
- GSM8117814 sgNTDHT-1 sgNTDHT
- GSM8117815 sgNTDHT-2 sgNTDHT
- GSM8117816 sgNTDHT-3 sgNTDHT
- GSM8117817 sgZNF397-1 sgZNF397
- GSM8117818 sgZNF397-2 sgZNF397
- GSM8117819 sgZNF397-3 sgZNF397
- GSM8117820 sgZNF397DHT-1 sgZNF397DHT
- GSM8117821 sgZNF397DHT-2 sgZNF397DHT
- GSM8117822 sgZNF397DHT-3 sgZNF397DHT
- GSE230600 ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer [ChIP-seq] 18 samples shares znf397, tet2-driven, ar-targeted, deficiency, plasticity, resistance, triggers, prostate
- GSE230602 ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer 51 samples shares znf397, tet2-driven, ar-targeted, deficiency, plasticity, resistance, triggers, prostate
- GSE230601 ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer [RNA-seq] 12 samples shares znf397, tet2-driven, ar-targeted, deficiency, plasticity, resistance, triggers, prostate
- GSE249439 ARID1A regulates DSB repair through chromatin organization and its deficiency triggers DNA damage-mediated immune response [ATAC-seq] 48 samples shares deficiency, triggers
- GSE309501 HDAC5 Deficiency Induces Intrinsic Resistance to KRASG12D Inhibition by Disrupting c-Myc Acetylation-Ubiquitination Homeostasis [ChIP-Seq] 6 samples shares deficiency, resistance
- GSE249492 ARID1A regulates DSB repair through chromatin organization and its deficiency triggers DNA damage-mediated immune response 280 samples shares deficiency, triggers
- GSE249442 ARID1A regulates DSB repair through chromatin organization and its deficiency triggers DNA damage-mediated immune response [ACT-seq] 48 samples shares deficiency, triggers
- GSE310927 PRMT5 Inhibition Triggers Functional ATM Deficiency and Sensitizes Pancreatic Cancer to CHK1 Blockade 36 samples shares deficiency, triggers
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.