← BioTransfer GEO Dataset Finder
GEO series

Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis [scRNA-seq]

GSE231934 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/04/28 Platform GPL24247
Summary
Characterized by lethal iron accumulation and lipid peroxidation, ferroptosis plays critical roles in liver injury, especially caused by ischemia/reperfusion (I/R) of hepatic inflow occlusion during liver operation. Here, we found that the excessive production of reactive oxygen species could decrease the expression of Interferon (IFN)-stimulated gene DExH-box helicase 58 (DHX58) in hepatocytes, and then promote hepatic ferroptosis, while pre-treatment using IFN-α increased DHX58 expression and prevented ferroptosis during I/R injury. Mechanistically, DHX58 with RNA-binding activity could constitutively associate the mRNA of glutathione peroxidase 4 (GPX4), a crucial ferroptosis suppressor, and then recruit the m6A reader YT521-B homology domain containing 2 (YTHDC2) to promote the translation of Gpx4 mRNA in m6A-dependent manner, thus enhancing GPX4 protein level and preventing hepatic ferroptosis.
Published in
Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
Jia KW, Yao RQ, Fan YW et al. · Military Medical Research 2024 · PMID 38622688 · doi:10.1186/s40779-024-00524-9
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE231934_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA970262 and SRA study SRP436455. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.