Effect of JAK inhibitors Upadacitinib or Baricitinib on gene expression during human monocyte-derived macrophage differentiation
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Macrophage re-programming by JAK inhibitors relies on MAFBCellular and molecular life sciences : CMLS · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE232044_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA970703 and SRA study SRP436646. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7310840 Untreated-GM-MØ macrophage donor1 rep1
- GSM7310841 Untreated-GM-MØ macrophage donor2 rep2
- GSM7310842 Untreated-GM-MØ macrophage donor3 rep3
- GSM7310843 Untreated-GM-MØ macrophage donor4 rep4
- GSM7310844 Baricitinib-GM-MØ macrophage donor1 rep1
- GSM7310845 Baricitinib-GM-MØ macrophage donor2 rep2
- GSM7310846 Baricitinib-GM-MØ macrophage donor3 rep3
- GSM7310847 Baricitinib-GM-MØ macrophage donor4 rep4
- GSM7310848 Upadacitinib-10-GM-MØ macrophage donor1 rep1
- GSM7310849 Upadacitinib-10-GM-MØ macrophage donor2 rep2
- GSM7310850 Upadacitinib-10-GM-MØ macrophage donor3 rep3
- GSM7310851 Upadacitinib-10-GM-MØ macrophage donor4 rep4
- GSM7310852 Upadacitinib-100-GM-MØ macrophage donor1 rep1
- GSM7310853 Upadacitinib-100-GM-MØ macrophage donor2 rep2
- GSM7310854 Upadacitinib-100-GM-MØ macrophage donor3 rep3
- GSM7310855 Upadacitinib-100-GM-MØ macrophage donor4 rep4
- GSE304272 Transcriptomic profiling of irradiated senescent IMR90 cells treated with CDK4/6 or JAK inhibitors 12 samples shares jak, inhibitors
- GSE337492 CD300A drives glioblastoma progression by orchestrating M2 macrophage polarization via the JAK2/STAT3 signaling axis 6 samples shares jak, macrophage
- GSE244130 Epigenomic Landscapes Define Differential JAK Inhibitor Sensitivity in IFN-γ-Primed Human Macrophages 16 samples shares jak, macrophage
- GSE240075 Gene expression in human monocyte-derived macrophages: effect of loss of MYC or USF1 30 samples shares monocyte-derived, macrophage
- GSE217996 Gene expression profile of human monocyte-derived macrophage stimulated with AGP, anti-CD74 antibody, and mycobacterium avium infaction 8 samples shares monocyte-derived, macrophage
- GSE236156 Mycobacterium tuberculosis induced interferon pathways distinguish responses of Human Alveolar Macrophages from Monocyte-Derived Macrophages 55 samples shares monocyte-derived, macrophage
- GSE232628 Expansion of profibrotic monocyte-derived alveolar macrophages in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19 46 samples shares monocyte-derived, macrophage
- GSE335752 Characterization of human M2-like (TGFbeta/IL10) vs M0 monocyte-derived macrophages 36 samples shares monocyte-derived, macrophage
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.