Gene expression alterations with Nkapl knockout or NKAPL frameshift mutation (M349fs)
RNA-seq (gene expression) · mouse · 26 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 26 samples: 9 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exitNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE232415_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA972306 and SRA study SRP437551. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 23 samples.
How we read this: 9 replicated groups read from 26 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7331931 21d Nkapl-WT rep1 21d Nkapl-WT
- GSM7331932 21d Nkapl-WT rep2 21d Nkapl-WT
- GSM7331933 21d Nkapl-WT rep3 21d Nkapl-WT
- GSM7331935 21d Nkapl-KO rep1 21d Nkapl-KO
- GSM7331936 21d Nkapl-KO rep2 21d Nkapl-KO
- GSM7331937 21d Nkapl-KO rep3 21d Nkapl-KO
- GSM7331938 21d Sox30-WT rep1 21d Sox30-WT
- GSM7331939 21d Sox30-WT rep2 21d Sox30-WT
- GSM7331940 21d Sox30-WT rep3 21d Sox30-WT
- GSM7331942 21d Sox30-KO rep1 21d Sox30-KO
- GSM7331943 21d Sox30-KO rep2 21d Sox30-KO
- GSM7331944 21d Sox30-KO rep3 21d Sox30-KO
- GSM7331945 21d Nkapl-WT rep1 (NE)
- GSM7331946 21d Nkapl-WT rep2 (NE)
- GSM7331947 21d Nkapl-WT rep3 (NE)
- GSM7331949 21d Nkapl TGdel/TGdel rep1 21d Nkapl TGdel/TGdel
- GSM7331950 21d Nkapl TGdel/TGdel rep2 21d Nkapl TGdel/TGdel
- GSM7331951 21d Nkapl TGdel/TGdel rep3 21d Nkapl TGdel/TGdel
- GSM8618769 21d Nkapl-WT_PS rep1 21d Nkapl-WT_PS
- GSM8618770 21d Nkapl-WT_PS rep2 21d Nkapl-WT_PS
- GSM8618771 21d Nkapl-WT_RS rep1 21d Nkapl-WT_RS
- GSM8618772 21d Nkapl-WT_RS rep2 21d Nkapl-WT_RS
- GSM8618773 21d Nkapl-KO_PS rep1 21d Nkapl-KO_PS
- GSM8618774 21d Nkapl-KO_PS rep2 21d Nkapl-KO_PS
- GSM8618775 21d Nkapl-KO_RS rep1 21d Nkapl-KO_RS
- GSM8618776 21d Nkapl-KO_RS rep2 21d Nkapl-KO_RS
- GSE279074 Comparative characterization of AHC associated mutations in ATP1A3 reveals diverse neurological alterations in mice. 48 samples shares alterations, mutation
- GSE292737 RNA-seq analysis in hepatocyte-specific Atg7-knockout mice with different p62 mutations [RNA-seq_T352A] 12 samples shares knockout, mutation
- GSE264514 Epigenetic and transcriptional alterations with Kmt2c and Kmt2d knockout 50 samples shares alterations, knockout
- GSE317602 Lung gene expression in WT and estrogen receptor alpha and beta knockout mice exposed to house dust mites 72 samples shares knockout
- GSE186648 Skeletal muscle mRNA expression in 25 mice with or without genetic defects of mitochondrial fatty acid oxidation (Acadl and Acadvl knockout) using RNA sequencing. 25 samples shares knockout
- GSE330380 The effects of adiponectin knockout on hepatic gene expression in male and female C57BL/6NCrl mice fed ad libitum or undergoing caloric restriction 22 samples shares knockout
- GSE284373 The effect of STING knockout on gene expression in cholestatic mice 20 samples shares knockout
- GSE315829 Investigate changes in gene expression and enriched pathways in endothelial cells following Liver endothelial Heg1 knockout. 13 samples shares knockout
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.