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Monomethylation of Lysine 27 at Histone 3 Confers Lifelong Susceptibility to Stress

GSE233419 Mus musculus (mouse) DNA methylation 72 samples Submitted 2024/07/05 Platform GPL21103
At a glance

DNA methylation · mouse · 72 samples

What it is
DNA methylationChemical marks on DNA that help switch genes on or off.
Organism
Mus musculus (mouse)
Samples
72 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Mono-methylation of lysine 27 at histone 3 confers lifelong susceptibility to stressNeuron · 2024
Summary (written by the submitters)
Histone post-translational modifications are critical for mediating persistent alterations in gene expression. By combining unbiased proteomics profiling, and genome-wide approaches, we uncovered a role for mono-methylation of lysine 27 at histone H3 (H3K27me1) in the enduring effects of stress. Specifically, mice exposed to early life stress (ELS) or to chronic social defeat stress (CSDS) in adulthood displayed increased enrichment of H3K27me1, and transient decrease in H3K27me2, in the nucleus accumbens (NAc), a key brain-reward region.
Published in
Mono-methylation of lysine 27 at histone 3 confers lifelong susceptibility to stress
Torres-Berrío A, Estill M, Patel V et al. · Neuron 2024 · PMID 38959894 · doi:10.1016/j.neuron.2024.06.006
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE233419_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.

Also filed as BioProject PRJNA976236 and SRA study SRP439542. Searching any of these in the dataset finder brings you back here.

Samples in this study

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