PHF6 regulates stress susceptibility in the pituitary intermediate lobe [RNA-seq]
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 6 × IL_control_wt vs 6 × IL_control_cko vs 6 × IL_restraint_wt vs 6 × IL_restraint_ckoGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Regulation of stress susceptibility by chromatin-binding protein PHF6 in the pituitary intermediate lobeMolecular psychiatry · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270456_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1126663 and SRA study SRP515382. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 4 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8343360 IL_control_wt1 IL_control_wt
- GSM8343361 IL_control_wt2 IL_control_wt
- GSM8343362 IL_control_wt3 IL_control_wt
- GSM8343363 IL_control_wt4 IL_control_wt
- GSM8343364 IL_control_wt5 IL_control_wt
- GSM8343365 IL_control_wt6 IL_control_wt
- GSM8343366 IL_control_cko1 IL_control_cko
- GSM8343367 IL_control_cko2 IL_control_cko
- GSM8343368 IL_control_cko3 IL_control_cko
- GSM8343369 IL_control_cko4 IL_control_cko
- GSM8343370 IL_control_cko5 IL_control_cko
- GSM8343371 IL_control_cko6 IL_control_cko
- GSM8343372 IL_restraint_wt1 IL_restraint_wt
- GSM8343373 IL_restraint_wt2 IL_restraint_wt
- GSM8343374 IL_restraint_wt3 IL_restraint_wt
- GSM8343375 IL_restraint_wt4 IL_restraint_wt
- GSM8343376 IL_restraint_wt5 IL_restraint_wt
- GSM8343377 IL_restraint_wt6 IL_restraint_wt
- GSM8343378 IL_restraint_cko1 IL_restraint_cko
- GSM8343379 IL_restraint_cko2 IL_restraint_cko
- GSM8343380 IL_restraint_cko3 IL_restraint_cko
- GSM8343381 IL_restraint_cko4 IL_restraint_cko
- GSM8343382 IL_restraint_cko5 IL_restraint_cko
- GSM8343383 IL_restraint_cko6 IL_restraint_cko
- GSE251656 Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice [RNA-seq] 12 samples shares susceptibility, rna-seq, stress
- GSE275729 Gene expression in Phf6-deleted and Phf6-intact foetal mouse cortical neurons and foetal mouse cortex assessed by RNA-seq 15 samples shares phf6, rna-seq
- GSE198499 Phf6 mutation induces leukemogenesis through altered chromatin state in mice (RNA-Seq) 11 samples shares phf6, rna-seq
- GSE330309 Impact of Sex Chromosomes and Gonad Type in Stress Susceptibility in Corticostriatal Brain Regions 96 samples shares susceptibility, stress
- GSE233419 Monomethylation of Lysine 27 at Histone 3 Confers Lifelong Susceptibility to Stress 72 samples shares susceptibility, stress
- GSE263021 TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states [RNA-seq - matched healthy and tumor tissues] 41 samples shares susceptibility, rna-seq
- GSE284730 Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress 39 samples shares susceptibility, stress
- GSE324816 Amygdala engram ensembles mediate differential susceptibility to short-term negative stress-induced remote depression in adolescent and adult mice 32 samples shares susceptibility, stress
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.