Apolipoprotein E2 expression drives increased brain exosome levels during aging to mitigate neuronal endosomal dysfunction
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 15 × Brain, APOE vs 5 × Brain, APOE4DGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Apolipoprotein E2 Expression Alters Endosomal Pathways in a Mouse Model With Increased Brain Exosome Levels During AgingTraffic (Copenhagen, Denmark) · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE234711_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA982803 and SRA study SRP442906. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 2 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7473648 FH124: Brain, APOE2 Brain, APOE
- GSM7473649 F74M: Brain, APOE2 Brain, APOE
- GSM7473650 F42N: Brain, APOE2 Brain, APOE
- GSM7473651 FH111: Brain, APOE2 Brain, APOE
- GSM7473652 F35J: Brain, APOE2 Brain, APOE
- GSM7473653 F61N: Brain, APOE3 Brain, APOE
- GSM7473654 F37N: Brain, APOE3 Brain, APOE
- GSM7473655 F39N: Brain, APOE3 Brain, APOE
- GSM7473656 F10N: Brain, APOE3 Brain, APOE
- GSM7473657 F64M: Brain, APOE3 Brain, APOE
- GSM7473658 F95K: Brain, APOE4 Brain, APOE
- GSM7473659 F78N: Brain, APOE4 Brain, APOE
- GSM7473660 F58M: Brain, APOE4 Brain, APOE
- GSM7473661 FH78: Brain, APOE4 Brain, APOE
- GSM7473662 FH66: Brain, APOE4 Brain, APOE
- GSM7473663 F12M: Brain, APOE4D Brain, APOE4D
- GSM7473664 FH85: Brain, APOE4D Brain, APOE4D
- GSM7473665 FH68: Brain, APOE4D Brain, APOE4D
- GSM7473666 F19M: Brain, APOE4D Brain, APOE4D
- GSM7473667 FH51: Brain, APOE4D Brain, APOE4D
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.