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Tumor cell intrinsic type I interferon signaling dictates CD47-SIRPα blockade immunotherapy via metabolic reprograming [dataset 1]

GSE235111 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2024/06/04 Platform GPL24247
Summary
Innate immune checkpoint has emerging as a highly potential target for cancer immunotherapy in recent years. The CD47-SIRPα axis is the best-studied innate checkpoint in cancer. However, the transcription profile of tumor cell duiring CD47-SIRPα blockade therapy remains unclear.
Published in
Metabolic reprograming mediated by tumor cell-intrinsic type I IFN signaling is required for CD47-SIRPα blockade efficacy
Zhou H, Wang W, Xu H et al. · Nature communications 2024 · PMID 38982116 · doi:10.1038/s41467-024-50136-z
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Also filed as BioProject PRJNA984610 and SRA study SRP444367. Searching any of these in the dataset finder brings you back here.

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