Preventing Site-specific Calpain Proteolysis of Junctophilin-2 Protects Against Stress-induced E-C Uncoupling and Heart Failure
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × WT Sham vs 4 × WT TAC vs 4 × JP2CR Sham vs 4 × JP2CR TACGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Preventing Site-Specific Calpain Proteolysis of Junctophilin-2 Protects Against Stress-Induced Excitation-Contraction Uncoupling and Heart Failure DevelopmentCirculation · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE235601_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA986537 and SRA study SRP445415. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7506071 WT Sham rep1 WT Sham
- GSM7506072 WT Sham rep2 WT Sham
- GSM7506073 WT Sham rep3 WT Sham
- GSM7506074 WT Sham rep4 WT Sham
- GSM7506075 WT TAC rep1 WT TAC
- GSM7506076 WT TAC rep2 WT TAC
- GSM7506077 WT TAC rep3 WT TAC
- GSM7506078 WT TAC rep4 WT TAC
- GSM7506079 JP2CR Sham rep1 JP2CR Sham
- GSM7506080 JP2CR Sham rep2 JP2CR Sham
- GSM7506081 JP2CR Sham rep3 JP2CR Sham
- GSM7506082 JP2CR Sham rep4 JP2CR Sham
- GSM7506083 JP2CR TAC rep1 JP2CR TAC
- GSM7506084 JP2CR TAC rep2 JP2CR TAC
- GSM7506085 JP2CR TAC rep3 JP2CR TAC
- GSM7506086 JP2CR TAC rep4 JP2CR TAC
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.