MERTK inhibition for the treatment of tissue fibrosis
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 154 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 154 samples: 30 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic diseaseScience translational medicine · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE235624_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA986569 and SRA study SRP441192. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 111 samples.
How we read this: 30 replicated groups read from 154 sample titles; they account for 111 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7450334 BDL WT ATAC
- GSM7450335 BDL KO ATAC
- GSM7450336 BDL WT GEX
- GSM7450338 BDL KO GEX
- GSM7453946 sham WT1 H3K4me1
- GSM7453947 sham WT1 H3K4me3
- GSM7453948 sham WT1 H3K27me3
- GSM7453949 sham WT1 H3K27ac
- GSM7453950 sham WT1 CTCF
- GSM7453951 sham WT1 p-Rpb1
- GSM7453952 sham WT2 H3K4me1 sham WT2 H3K4me
- GSM7453953 sham WT2 H3K4me3 sham WT2 H3K4me
- GSM7453954 sham WT2 H3K27me3
- GSM7453955 sham WT2 H3K27ac
- GSM7453956 sham WT2 CTCF
- GSM7453957 sham WT2 p-Rpb1
- GSM7453958 sham KO1 H3K4me1
- GSM7453959 sham KO1 H3K4me3
- GSM7453960 sham KO1 H3K27me3
- GSM7453961 sham KO1 H3K27ac
- GSM7453962 sham KO1 CTCF
- GSM7453963 sham KO1 p-Rpb1
- GSM7453964 sham KO2 H3K4me1
- GSM7453965 sham KO2 H3K4me3
- GSM7453966 sham KO2 H3K27me3
- GSM7453967 sham KO2 H3K27ac
- GSM7453968 sham KO2 CTCF
- GSM7453969 sham KO2 p-Rpb1
- GSM7453970 BDL WT1 H3K4me1 BDL WT1 H3K4me
- GSM7453971 BDL WT1 H3K4me3 BDL WT1 H3K4me
- GSM7453972 BDL WT1 H3K27me3
- GSM7453973 BDL WT1 H3K27ac
- GSM7453974 BDL WT1 CTCF
- GSM7453975 BDL WT1 p-Rpb1
- GSM7453976 BDL WT2 H3K4me1 BDL WT2 H3K4me
- GSM7453977 BDL WT2 H3K4me3 BDL WT2 H3K4me
- GSM7453978 BDL WT2 H3K27me3
- GSM7453979 BDL WT2 H3K27ac
- GSM7453980 BDL WT2 CTCF
- GSM7453981 BDL WT2 p-Rpb1
+ 114 more — browse all 154 samples with per-sample file links →
- GSE268791 TGF-b/Smad3 inhibition synergizes with PPARg agonism to reduce fibrosis and enhance functional beige adipogenesis 18 samples shares inhibition, fibrosis
- GSE288662 Role of progesterone receptor in inguinal hernia formation via skeletal muscle fibrosis [Hernia_Multiomics] 20 samples shares fibrosis
- GSE325502 Gene expression profile for Gpt2 WT and Gpt2 KO mouse brain tissues with vehicle or dm-αKG treatment 36 samples shares treatment
- GSE281151 Transient histone deacetylase inhibition induces cellular memory of gene expression and three-dimensional genome folding 259 samples shares inhibition
- GSE318028 Pharmacological inhibition of FKBP51 mitigates early life adversity-induced social deficits 246 samples shares inhibition
- GSE332646 Bulk RNA-seq of juvenile mouse liver following NDMA or saline treatment in WT and Mgmt-/- genotypes across multiple timepoints 214 samples shares treatment
- GSE314584 Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis 124 samples shares fibrosis
- GSE289939 Gene expression profiling of mouse lung tissue in a bleomycin-induced pulmonary fibrosis model 15 samples shares fibrosis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.