A non-canonical repressor function of JUN restrains YAP activity and suppresses YAP-dependent liver cancer growth [iYAP5SA_10A_JUN_oe_antibodies_for_JUN_YAP_TEAD]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 54 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 54 samples: 18 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A non-canonical repressor function of JUN restrains YAP activity and liver cancer growthThe EMBO journal · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE235965_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA988099 and SRA study SRP446147. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 54 samples.
How we read this: 18 replicated groups read from 54 sample titles; they account for 54 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7512477 10A_ev_etoh, YAP1, replicate1 10A_ev_etoh, YAP1,
- GSM7512478 10A_ev_etoh,TEAD1, replicate1 10A_ev_etoh,TEAD1,
- GSM7512479 10A_ev_etoh, JUN, replicate1 10A_ev_etoh, JUN,
- GSM7512480 10A_ev_etoh, IgG, replicate1 10A_ev_etoh, IgG,
- GSM7512481 10A_ev_dox, YAP1, replicate1 10A_ev_dox, YAP1,
- GSM7512482 10A_ev_dox,TEAD1, replicate1 10A_ev_dox,TEAD1,
- GSM7512483 10A_ev_dox, JUN, replicate1 10A_ev_dox, JUN,
- GSM7512484 10A_ev_dox, IgG, replicate1 10A_ev_dox, IgG,
- GSM7512485 10A_JUNoe_etoh, YAP1, replicate1 10A_JUNoe_etoh, YAP1,
- GSM7512486 10A_JUNoe_etoh,TEAD1, replicate1 10A_JUNoe_etoh,TEAD1,
- GSM7512487 10A_JUNoe_etoh, JUN, replicate1 10A_JUNoe_etoh, JUN,
- GSM7512488 10A_JUNoe_etoh, IgG, replicate1 10A_JUNoe_etoh, IgG,
- GSM7512489 10A_JUNoe_dox, YAP1, replicate1 10A_JUNoe_dox, YAP1,
- GSM7512490 10A_JUNoe_dox,TEAD1, replicate1 10A_JUNoe_dox,TEAD1,
- GSM7512491 10A_JUNoe_dox, JUN, replicate1 10A_JUNoe_dox, JUN,
- GSM7512492 10A_JUNoe_dox, IgG, replicate1 10A_JUNoe_dox, IgG,
- GSM7512493 10A_ev_etoh, YAP1, replicate2 10A_ev_etoh, YAP1,
- GSM7512494 10A_ev_etoh,TEAD1, replicate2 10A_ev_etoh,TEAD1,
- GSM7512495 10A_ev_etoh, JUN, replicate2 10A_ev_etoh, JUN,
- GSM7512496 10A_ev_etoh, IgG, replicate2 10A_ev_etoh, IgG,
- GSM7512497 10A_ev_dox, YAP1, replicate2 10A_ev_dox, YAP1,
- GSM7512498 10A_ev_dox,TEAD1, replicate2 10A_ev_dox,TEAD1,
- GSM7512499 10A_ev_dox, JUN, replicate2 10A_ev_dox, JUN,
- GSM7512500 10A_ev_dox, IgG, replicate2 10A_ev_dox, IgG,
- GSM7512501 10A_JUNoe_etoh, YAP1, replicate2 10A_JUNoe_etoh, YAP1,
- GSM7512502 10A_JUNoe_etoh,TEAD1, replicate2 10A_JUNoe_etoh,TEAD1,
- GSM7512503 10A_JUNoe_etoh, JUN, replicate2 10A_JUNoe_etoh, JUN,
- GSM7512504 10A_JUNoe_etoh, IgG, replicate2 10A_JUNoe_etoh, IgG,
- GSM7512505 10A_JUNoe_dox, YAP1, replicate2 10A_JUNoe_dox, YAP1,
- GSM7512506 10A_JUNoe_dox,TEAD1, replicate2 10A_JUNoe_dox,TEAD1,
- GSM7512507 10A_JUNoe_dox, JUN, replicate2 10A_JUNoe_dox, JUN,
- GSM7512508 10A_JUNoe_dox, IgG, replicate2 10A_JUNoe_dox, IgG,
- GSM8240981 10A_ev_etoh, H3K4me1, rep1 10A_ev_etoh, H3K4me1,
- GSM8240982 10A_ev_etoh, H3K27ac, rep1 10A_ev_etoh, H3K27ac,
- GSM8240983 10A_ev_etoh, H3K4me1, rep2 10A_ev_etoh, H3K4me1,
- GSM8240984 10A_ev_etoh, H3K27ac, rep2 10A_ev_etoh, H3K27ac,
- GSM8240985 10A_ev_etoh, H3K4me1, rep3 10A_ev_etoh, H3K4me1,
- GSM8240986 10A_ev_etoh, H3K27ac, rep3 10A_ev_etoh, H3K27ac,
- GSM8240987 10A_ev_etoh, YAP1, rep3 10A_ev_etoh, YAP1,
- GSM8240988 10A_ev_etoh,TEAD1, rep3 10A_ev_etoh,TEAD1,
+ 14 more — browse all 54 samples with per-sample file links →
- GSE235960 A non-canonical repressor function of JUN restrains YAP activity and suppresses YAP-dependent liver cancer growth [CUT&RUN] 64 samples shares jun, yap, non-canonical, yap-dependent, suppresses
- GSE235968 A non-canonical repressor function of JUN restrains YAP activity and suppresses YAP-dependent liver cancer growth 178 samples shares jun, yap, non-canonical, yap-dependent, suppresses
- GSE305254 Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in Hippo-dependent cancer models 299 samples shares tead, yap
- GSE305227 Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in Hippo-dependent cancer models [Quant-seq] 149 samples shares tead, yap
- GSE305224 Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in Hippo-dependent cancer models [RNA-seq] 120 samples shares tead, yap
- GSE330470 ChIP-seq and CUT&Tag profiling of the genome binding of YAP/TAZ-TEAD and SMAD3 in the human HCC cell line HCCLM3 [ChIP-seq] 55 samples shares tead, yap
- GSE249903 Activation of hepatocyte growth factor (HGF)/MET signaling as a mechanism of acquired resistance to a novel YAP1/TEAD small molecule inhibitor. 49 samples shares tead, yap
- GSE330305 Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in Hippo-dependent cancer models [ATAC-seq] 30 samples shares tead, yap
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.