A non-canonical repressor function of JUN restrains YAP activity and suppresses YAP-dependent liver cancer growth
RNA-seq (gene expression) · human · 178 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 178 samples: 55 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A non-canonical repressor function of JUN restrains YAP activity and liver cancer growthThe EMBO journal · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE235968_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA988093 and SRA study SRP446147. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 178 samples.
How we read this: 55 replicated groups read from 178 sample titles; they account for 178 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7506241 SAM cells, NTC rep1 SAM cells, NTC
- GSM7506242 SAM cells, NTC rep2 SAM cells, NTC
- GSM7506243 SAM cells, NTC rep3 SAM cells, NTC
- GSM7506244 SAM cells, sgJUN#1 rep1 SAM cells, sgJUN#1
- GSM7506245 SAM cells, sgJUN#1 rep2 SAM cells, sgJUN#1
- GSM7506246 siCtrl rep1 siCtrl
- GSM7506247 siYAP/TAZ rep1 siYAP/TAZ
- GSM7506248 siCtrl rep2 siCtrl
- GSM7506249 siYAP/TAZ rep2 siYAP/TAZ
- GSM7506250 siCtrl rep3 siCtrl
- GSM7506251 siYAP/TAZ rep3 siYAP/TAZ
- GSM7506260 vector EtOH rep1 vector EtOH
- GSM7506261 vector Dox rep1 vector Dox
- GSM7506262 JUN EtOH rep1 JUN EtOH
- GSM7506263 JUN Dox rep1 JUN Dox
- GSM7506264 vector EtOH rep2 vector EtOH
- GSM7506265 vector Dox rep2 vector Dox
- GSM7506266 JUN EtOH rep2 JUN EtOH
- GSM7506267 JUN Dox rep2 JUN Dox
- GSM7506268 vector EtOH rep3 vector EtOH
- GSM7506269 vector Dox rep3 vector Dox
- GSM7506270 JUN EtOH rep3 JUN EtOH
- GSM7506271 JUN Dox rep3 JUN Dox
- GSM7506272 no 4sU Ctrl rep1 no 4sU Ctrl
- GSM7506273 DMSO 4sU rep1 DMSO 4sU
- GSM7506274 IAA 4sU rep1 IAA 4sU
- GSM7506275 no 4sU Ctrl rep2 no 4sU Ctrl
- GSM7506276 DMSO 4sU rep2 DMSO 4sU
- GSM7506277 IAA 4sU rep2 IAA 4sU
- GSM7506278 no 4sU Ctrl rep3 no 4sU Ctrl
- GSM7506279 DMSO 4sU rep3 DMSO 4sU
- GSM7506280 IAA 4sU rep3 IAA 4sU
- GSM7512367 10A_ev_etoh, YAP1, rep1 10A_ev_etoh, YAP1,
- GSM7512368 10A_ev_etoh, JUN, rep1 10A_ev_etoh, JUN,
- GSM7512369 10A_ev_etoh, cFOS, rep1 10A_ev_etoh, cFOS,
- GSM7512370 10A_ev_etoh, NCOR1, rep1 10A_ev_etoh, NCOR1,
- GSM7512371 10A_ev_etoh, ARID1A, rep1 10A_ev_etoh, ARID1A,
- GSM7512372 10A_ev_etoh, IgG, rep1 10A_ev_etoh, IgG,
- GSM7512373 10A_ev_dox, YAP1, rep1 10A_ev_dox, YAP1,
- GSM7512374 10A_ev_dox, JUN, rep1 10A_ev_dox, JUN,
+ 138 more — browse all 178 samples with per-sample file links →
- GSE235960 A non-canonical repressor function of JUN restrains YAP activity and suppresses YAP-dependent liver cancer growth [CUT&RUN] 64 samples shares jun, yap, non-canonical, yap-dependent, suppresses, repressor, restrains, activity
- GSE235965 A non-canonical repressor function of JUN restrains YAP activity and suppresses YAP-dependent liver cancer growth [iYAP5SA_10A_JUN_oe_antibodies_for_JUN_YAP_TEAD] 54 samples shares jun, yap, non-canonical, yap-dependent, suppresses, repressor, restrains, activity
- GSE305254 Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in Hippo-dependent cancer models 299 samples shares yap, activity
- GSE305227 Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in Hippo-dependent cancer models [Quant-seq] 149 samples shares yap, activity
- GSE305224 Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in Hippo-dependent cancer models [RNA-seq] 120 samples shares yap, activity
- GSE330305 Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in Hippo-dependent cancer models [ATAC-seq] 30 samples shares yap, activity
- GSE227974 MY-COMP, an inhibitor of the transcriptional activity of YAP-B-MYB, identifies NEK2 as a novel mediator of YAP oncogenesis in uveal melanoma cells 29 samples shares yap, activity
- GSE227973 MY-COMP, an inhibitor of the transcriptional activity of YAP-B-MYB, identifies NEK2 as a novel mediator of YAP oncogenesis in uveal melanoma cells [RNA-seq] 21 samples shares yap, activity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.