Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activity
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 89 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 89 samples: 81 distinct titles, 8 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE236415_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA990766 and SRA study SRP447177. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 89 sample titles: 81 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7532808 ATACseq, DMSO, 30 min, E2, 45 min
- GSM7532809 ATACseq, DMSO, 30 min, VEH, 45 min
- GSM7532810 ATACseq, ICRF-187, 30 min, E2, 45 min
- GSM7532811 ATACseq, ICRF-187, 30 min, VEH, 45 min
- GSM7532882 RAD21 ChIPseq, siC, VEH, 45 min
- GSM7532883 RAD21 ChIPseq, siC, E2, 45 min
- GSM7532884 RAD21 ChIPseq, siTOP2B, VEH, 45 min
- GSM7532886 RAD21 ChIPseq, siTOP2B, E2, 45 min
- GSM7532887 ERA ChIPseq, VEH, 45 min
- GSM7532888 ERA ChIPseq, E2, 45 min
- GSM7532889 TOP2B ChIPseq
- GSM7532890 TOP2B ChIPseq, VEH, 45 min
- GSM7532891 TOP2B ChIPseq, E2, 45 min
- GSM7532893 TOP2A ChIPseq, VEH, 45 min, rep1
- GSM7532894 TOP2A ChIPseq, E2, 45 min, rep1
- GSM7532895 TOP2A ChIPseq, VEH, 45 min, rep2
- GSM7532896 TOP2A ChIPseq, E2, 45 min, rep2
- GSM7532897 ZATT ChIPseq, VEH, 45 min, rep2
- GSM7532898 ZATT ChIPseq, E2, 45 min, rep2
- GSM7532899 POLII ChIPseq, DMSO (Merb), VEH, 45 min
- GSM7532901 POLII ChIPseq, DMSO (Merb), E2, 45 min
- GSM7532902 POLII ChIPseq, MERB, VEH, 45 min
- GSM7532903 POLII ChIPseq, MERB, E2, 45 min
- GSM7532904 POLII ChIPseq, DMSO (ICRF-187), VEH, 45 min
- GSM7532905 POLII ChIPseq, DMSO (ICRF-187), E2, 45 min
- GSM7532906 POLII ChIPseq, ICRF-187, VEH, 45 min
- GSM7532908 POLII ChIPseq, ICRF-187, E2, 45 min
- GSM7532909 POLII ChIPseq, siC (siTOP2B), VEH, 45 min
- GSM7532910 POLII ChIPseq, siC (siTOP2B), E2, 45 min
- GSM7532911 POLII ChIPseq, siTOP2B, VEH, 45 min
- GSM7532912 POLII ChIPseq, siTOP2B, E2, 45 min
- GSM7532913 POLII ChIPseq, siC (siTOP2A), VEH, 45 min
- GSM7532915 POLII ChIPseq, siC (siTOP2A), E2, 45 min
- GSM7532916 POLII ChIPseq, siTOP2A, VEH, 45 min
- GSM7532917 POLII ChIPseq, siTOP2A, E2, 45 min
- GSM7532918 POLII ChIPseq, siC (siZATT), VEH, 45 min
- GSM7532919 POLII ChIPseq, siC (siZATT), E2, 45 min
- GSM7532920 POLII ChIPseq, siZATT, VEH, 45 min
- GSM7532921 POLII ChIPseq, siZATT, E2, 45 min
- GSM7532922 Input RAD21 ChIPseq, siC, VEH, 45 min
+ 49 more — browse all 89 samples with per-sample file links →
- GSE304612 Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML. [ChIP-seq] 95 samples shares inhibition, activity
- GSE278245 Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers 21 samples shares topological
- GSE293334 Allelic topological centering by transcription factors drives oncogenic multi-enhancer transcriptional regulation [ChIP-seq] 60 samples shares topological
- GSE323965 Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer [RNA-Seq] 39 samples shares inhibition
- GSE199913 KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage 231 samples shares inhibition
- GSE254732 Inhibition of PCSK9 with evolocumab modulates lipoproteins and monocyte activation in high-risk ASCVD subjects 215 samples shares inhibition
- GSE300177 Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia 194 samples shares inhibition
- GSE299851 Transcriptional changes in response to TGFB in human pancreatic stellate cells with inhibition of PIN1 18 samples shares inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.