An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome
Non-coding RNA profiling · human · 12 samples
- What it is
- Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion SyndromeeLife · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE236596_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
Also filed as BioProject PRJNA991612 and SRA study SRP447467. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7559491 Q5_1, ctrl batch 1 Q5_1, ctrl
- GSM7559492 Q5_2, ctrl batch 2 Q5_2, ctrl
- GSM7559493 Q5_3, ctrl batch 3 Q5_3, ctrl
- GSM7559494 Q6_1, case batch 1 Q6_1, case
- GSM7559495 Q6_2, case batch 2 Q6_2, case
- GSM7559496 Q6_3, case batch 3 Q6_3, case
- GSM7559497 Q5_1, ctrl batch 1 Q5_1, ctrl
- GSM7559498 Q5_2, ctrl batch 2 Q5_2, ctrl
- GSM7559499 Q5_3, ctrl batch 3 Q5_3, ctrl
- GSM7559500 Q6_1, case batch 1 Q6_1, case
- GSM7559501 Q6_2, case batch 2 Q6_2, case
- GSM7559502 Q6_3, case batch 3 Q6_3, case
- GSE244010 Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome and schizophrenia. 26 samples shares 22q11, deletion
- GSE308782 Telomerase Dysfunction Strategy Overcomes Targeted Therapy Induced Drug Tolerant Persister in Pan-cancer via SUCLG2 downregulation 36 samples shares dysfunction, strategy
- GSE316654 Microbiota-Derived Isovalerate Ameliorates Sex-Specific Gut Barrier Dysfunction in Malnutrition 16 samples shares dysfunction, ameliorate
- GSE243068 T cell dysfunction in ARDS based on miRNA and mRNA integration analysis 98 samples shares dysfunction
- GSE318420 Immunosuppressive monocytes are enriched in hepatocellular carcinoma patients with liver dysfunction in a phase II trial of combination sorafenib and nivolumab 210 samples shares dysfunction
- GSE313642 Immunosuppressive monocytes are enriched in hepatocellular carcinoma patients with liver dysfunction in a phase II trial of combination sorafenib and nivolumab [CITE-Seq] 194 samples shares dysfunction
- GSE336982 Obesity Promotes Lung Carcinogenesis Through Airway Immune Dysfunction 183 samples shares dysfunction
- GSE261070 Dysfunctional neutrophil Type 1 interferon responses in preschool children with recurrent wheezing and IL-4-mediated aeroallergen sensitization 134 samples shares dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.