The intellectual disability risk gene Kdm5b regulates long term memory consolidation in the hippocampus
RNA-seq (gene expression) · mouse · 44 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 44 samples: 16 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The Intellectual Disability Risk Gene Kdm5b Regulates Long-Term Memory Consolidation in the HippocampusThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE240887_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1005646 and SRA study SRP455234. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 44 samples.
How we read this: 16 replicated groups read from 44 sample titles; they account for 44 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7711365 WT_M_0h_cohort2_1 WT_M_0h_cohort2
- GSM7711366 WT_M_0h_cohort2_2 WT_M_0h_cohort2
- GSM7711367 WT_M_0h_cohort2_3 WT_M_0h_cohort2
- GSM7711368 WT_F_0h_cohort2_1 WT_F_0h_cohort2
- GSM7711369 WT_F_0h_cohort2_2 WT_F_0h_cohort2
- GSM7711370 WT_F_0h_cohort2_3 WT_F_0h_cohort2
- GSM7711371 DARID_M_0h_cohort2_1 DARID_M_0h_cohort2
- GSM7711372 DARID_M_0h_cohort2_2 DARID_M_0h_cohort2
- GSM7711373 DARID_M_0h_cohort2_3 DARID_M_0h_cohort2
- GSM7711374 DARID_F_0h_cohort2_1 DARID_F_0h_cohort2
- GSM7711375 DARID_F_0h_cohort2_2 DARID_F_0h_cohort2
- GSM7711376 DARID_F_0h_cohort2_3 DARID_F_0h_cohort2
- GSM7711377 WT_M_1h_cohort2_1 WT_M_1h_cohort2
- GSM7711378 WT_M_1h_cohort2_2 WT_M_1h_cohort2
- GSM7711379 WT_M_1h_cohort2_3 WT_M_1h_cohort2
- GSM7711380 WT_F_1h_cohort2_1 WT_F_1h_cohort2
- GSM7711381 WT_F_1h_cohort2_2 WT_F_1h_cohort2
- GSM7711382 WT_F_1h_cohort2_3 WT_F_1h_cohort2
- GSM7711383 DARID_M_1h_cohort2_1 DARID_M_1h_cohort2
- GSM7711384 DARID_M_1h_cohort2_2 DARID_M_1h_cohort2
- GSM7711385 DARID_M_1h_cohort2_3 DARID_M_1h_cohort2
- GSM7711386 DARID_F_1h_cohort2_1 DARID_F_1h_cohort2
- GSM7711387 DARID_F_1h_cohort2_2 DARID_F_1h_cohort2
- GSM7711388 DARID_F_1h_cohort2_3 DARID_F_1h_cohort2
- GSM7711389 WT_M_3h_cohort2_1 WT_M_3h_cohort2
- GSM7711390 WT_M_3h_cohort2_2 WT_M_3h_cohort2
- GSM7711391 WT_M_3h_cohort2_3 WT_M_3h_cohort2
- GSM7711392 WT_F_3h_cohort2_1 WT_F_3h_cohort2
- GSM7711393 WT_F_3h_cohort2_2 WT_F_3h_cohort2
- GSM7711394 WT_F_3h_cohort2_3 WT_F_3h_cohort2
- GSM7711395 DARID_M_3h_cohort2_1 DARID_M_3h_cohort2
- GSM7711396 DARID_M_3h_cohort2_2 DARID_M_3h_cohort2
- GSM7711397 DARID_M_3h_cohort2_3 DARID_M_3h_cohort2
- GSM7711398 DARID_F_3h_cohort2_1 DARID_F_3h_cohort2
- GSM7711399 DARID_F_3h_cohort2_2 DARID_F_3h_cohort2
- GSM7711400 DARID_F_3h_cohort2_3 DARID_F_3h_cohort2
- GSM7777993 WT_M_0h_cohort1_1 WT_M_0h_cohort1
- GSM7777994 WT_M_0h_cohort1_2 WT_M_0h_cohort1
- GSM7777995 WT_F_0h_cohort1_1 WT_F_0h_cohort1
- GSM7777996 WT_F_0h_cohort1_2 WT_F_0h_cohort1
+ 4 more — browse all 44 samples with per-sample file links →
- GSE213745 Disruption of the intellectual disability-linked gene Hs6st2 in mice decreases heparan sulfate 6-O-sulfation in the brain and impairs memory 15 samples shares intellectual, disability, memory
- GSE300675 Neuron type-specific mRNA translation programs provide a gateway for memory consolidation. 153 samples shares consolidation, memory
- GSE252400 Epigenetic Modulation to perturb the SYNGAP1 Intellectual Disability (ID) that ameliorates synaptic and behavioural deficits 18 samples shares intellectual, disability
- GSE261404 Hippocampal DNA methylation promote memory persistence by facilitating systems consolidation and cortical engram stabilization 16 samples shares consolidation, memory
- GSE290477 Dexmedetomidine Inhibits Fear Memory Consolidation via the Astrocyte-Specific Srebf1-Phgdh Pathway in the Prelimbic Prefrontal Cortex 12 samples shares consolidation, memory
- GSE293538 Cadmium-induced gut dysbiosis precedes the onset of hippocampus-dependent learning and memory deficits in mice 10 samples shares hippocampus, memory
- GSE156004 Functional heterogeneity of dentate gyrus mossy cells along the longitudinal axis of the hippocampus 10 samples shares hippocampus, long
- GSE313803 HNRNPH2 variant linked to intellectual disability disrupts myelination by impairing oligodendrocyte differentiation 7 samples shares intellectual, disability
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.