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Effect of NIBR-LTSi treatment on gene expression in mouse intestinal organoids

GSE240969 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/07 Platform GPL24247
Summary
The YAP/Hippo pathway is a key regulator of organ growth and size regulation and is involved in safeguarding multiple tissue stem cell compartments. LATS kinases phosphorylate and thereby inactivate YAP, thus representing a potential direct drug target for promoting tissue regeneration. We report on the gene expression changes associated with YAP activation by the selective small molecule LATS kinase inhibitor NIBR-LTSi in mouse intestinal organoids. We show that, LATS-LTSi activates YAP signalling, promotes proliferation, induces a regenerative phenotype and blocks differentiation.
Published in
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
Namoto K, Baader C, Orsini V et al. · Cell stem cell 2024 · PMID 38579685 · doi:10.1016/j.stem.2024.03.003
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Also filed as BioProject PRJNA1005950 and SRA study SRP455383. Searching any of these in the dataset finder brings you back here.

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