FTO-mediated RNA m6A demethylation regulates aggressive behavior and inflammation of fibroblast-like synoviocytes
DNA methylation · human · 18 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE241254_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1007578 and SRA study SRP456075. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7720011 RA1 shCONTROL
- GSM7720012 RA1 shFTO
- GSM7720013 RA3 shCONTROL
- GSM7720014 RA3 shFTO
- GSM7720015 RA5 shCONTROL
- GSM7720016 RA5 shFTO
- GSM7720077 RA1 shCONTROL input
- GSM7720080 RA1 shCONTROL ip
- GSM7720083 RA1 shFTO input
- GSM7720086 RA1 shFTO ip
- GSM7720089 RA3 shCONTROL input
- GSM7720093 RA3 shCONTROL ip
- GSM7720096 RA3 shFTO input
- GSM7720099 RA3 shFTO ip
- GSM7720100 RA5 shCONTROL input
- GSM7720101 RA5 shCONTROL ip
- GSM7720102 RA5 shFTO input
- GSM7720103 RA5 shFTO ip
- GSE276473 DLX4 regulates the invasiveness of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and a cancer transcriptomic signature 6 samples shares fibroblast-like, synoviocytes
- GSE309533 snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice 11 samples shares fibroblast-like, synoviocytes
- GSE266310 Effects of methotrexate and tofacitinib on gene expression of activated rheumatoid arthritis fibroblast-like synoviocytes 9 samples shares fibroblast-like, synoviocytes
- GSE301891 RNA-Seq Analysis of Fibroblast-Like Synoviocytes Treated With Lutein in a Rheumatoid Arthritis Context 6 samples shares fibroblast-like, synoviocytes
- GSE241249 Transcriptome profile of fibroblast-like synoviocytes with FTO knockdown 6 samples shares fibroblast-like, synoviocytes
- GSE280445 Effect of MSMP inhibition on the gene expression profiles of rheumatoid fibroblast-like synoviocytes 6 samples shares fibroblast-like, synoviocytes
- GSE268214 Effects of NCL Knockdown on Fibroblast-Like Synoviocytes 6 samples shares fibroblast-like, synoviocytes
- GSE37427 Expression data from fibroblast-like synoviocytes (FLS) transfected with mimic-miR-23b or mimic-NC 2 samples shares fibroblast-like, synoviocytes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.