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T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis

GSE243018 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/10 Platform GPL24247
Summary
Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease (AD) remains uncertain, despite age being a major risk factor. Using a mouse model of AD, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.
Published in
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis
Kedia S, Ji H, Feng R et al. · Nature neuroscience 2024 · PMID 38937583 · doi:10.1038/s41593-024-01682-8
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Also filed as BioProject PRJNA1015730 and SRA study SRP460007. Searching any of these in the dataset finder brings you back here.

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