EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (RNA-seq)
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3Molecular cancer research : MCR · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE243183_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1017354 and SRA study SRP460509. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7780321 TC-32 siNEG, rep 1 TC-32 siNEG,
- GSM7780322 TC-32 siNEG, rep 2 TC-32 siNEG,
- GSM7780323 TC-32 siNEG, rep 3 TC-32 siNEG,
- GSM7780324 TC-32 siFLI1, rep 1 TC-32 siFLI1,
- GSM7780325 TC-32 siFLI1, rep 2 TC-32 siFLI1,
- GSM7780326 TC-32 siFLI1, rep 3 TC-32 siFLI1,
- GSM7780327 TC-71 siNEG, rep 1 TC-71 siNEG,
- GSM7780328 TC-71 siNEG, rep 2 TC-71 siNEG,
- GSM7780329 TC-71 siNEG, rep 3 TC-71 siNEG,
- GSM7780330 TC-71 siFLI1, rep 1 TC-71 siFLI1,
- GSM7780331 TC-71 siFLI1, rep 2 TC-71 siFLI1,
- GSM7780332 TC-71 siFLI1, rep 3 TC-71 siFLI1,
- GSM7780333 A673 siNEG, rep 1 A673 siNEG,
- GSM7780334 A673 siNEG, rep 2 A673 siNEG,
- GSM7780335 A673 siNEG, rep 3 A673 siNEG,
- GSM7780336 A673 siFLI1, rep 1 A673 siFLI1,
- GSM7780337 A673 siFLI1, rep 2 A673 siFLI1,
- GSM7780338 A673 siFLI1, rep 3 A673 siFLI1,
- GSE243279 EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (RNA-seq) 9 samples shares ewsr1, fli1, ets1, oncoproteins, rna-seq, fusion
- GSE243171 EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (ChIP-seq) 22 samples shares ewsr1, fli1, ets1, oncoproteins, fusion
- GSE243277 EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (CUT&RUN) 14 samples shares ewsr1, fli1, ets1, oncoproteins, fusion
- GSE243184 ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3 63 samples shares ewsr1, fli1, ets1, fusion
- GSE290895 Rewiring the fusion oncoprotein EWSR1::FLI1 in Ewing scarcoma with bivalent small molecules [RNA-Seq] 54 samples shares ewsr1, fli1, rna-seq, fusion
- GSE272957 EWSR1/FLI1 Expression in Human Mesenchymal Stem Cells derived from Experimental Teratomas Leads to Ewing´s Sarcoma Tumorigenesis [RNA-seq] 16 samples shares ewsr1, fli1, rna-seq
- GSE290894 Rewiring the fusion oncoprotein EWSR1::FLI1 in Ewing scarcoma with bivalent small molecules [ChIP-Seq] 24 samples shares ewsr1, fli1, fusion
- GSE290893 Rewiring the fusion oncoprotein EWSR1::FLI1 in Ewing scarcoma with bivalent small molecules [ATAC-seq] 4 samples shares ewsr1, fli1, fusion
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.