ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 63 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 63 samples: 23 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3Molecular cancer research : MCR · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE243184_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1017350 and SRA study SRP460356. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 55 samples.
How we read this: 23 replicated groups read from 63 sample titles; they account for 55 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7780176 TC-32 siNEG, Input, rep 1 TC-32 siNEG, Input,
- GSM7780177 TC-32 siNEG, Input, rep 2 TC-32 siNEG, Input,
- GSM7780178 TC-32 siNEG, ETS1, rep 1 TC-32 siNEG, ETS1,
- GSM7780179 TC-32 siNEG, ETS1, rep 2 TC-32 siNEG, ETS1,
- GSM7780180 TC-32 siFLI1, Input, rep 1 TC-32 siFLI1, Input,
- GSM7780181 TC-32 siFLI1, Input, rep 2 TC-32 siFLI1, Input,
- GSM7780182 TC-32 siFLI1, ETS1, rep 1 TC-32 siFLI1, ETS1,
- GSM7780183 TC-32 siFLI1, ETS1, rep 2 TC-32 siFLI1, ETS1,
- GSM7780184 TC-32 siNEG, Input, rep 1_I
- GSM7780185 TC-32 siNEG, Input, rep 2_II
- GSM7780186 TC-32 siNEG, H3K27ac, rep 1_I
- GSM7780187 TC-32 siNEG, H3K27ac, rep 2_II
- GSM7780188 TC-32 siNEG, H3K4me3, rep 1 TC-32 siNEG, H3K4me3,
- GSM7780189 TC-32 siNEG, H3K4me3, rep 2 TC-32 siNEG, H3K4me3,
- GSM7780192 TC-32 siFLI1, Input, rep 1_I
- GSM7780193 TC-32 siFLI1, Input, rep 2_II
- GSM7780194 TC-32 siFLI1, H3K27ac, rep 1 TC-32 siFLI1, H3K27ac,
- GSM7780195 TC-32 siFLI1, H3K27ac, rep 2 TC-32 siFLI1, H3K27ac,
- GSM7780196 TC-32 siFLI1, H3K4me3, rep 1 TC-32 siFLI1, H3K4me3,
- GSM7780197 TC-32 siFLI1, H3K4me3, rep 2 TC-32 siFLI1, H3K4me3,
- GSM7780321 TC-32 siNEG, rep 1 TC-32 siNEG,
- GSM7780322 TC-32 siNEG, rep 2 TC-32 siNEG,
- GSM7780323 TC-32 siNEG, rep 3 TC-32 siNEG,
- GSM7780324 TC-32 siFLI1, rep 1 TC-32 siFLI1,
- GSM7780325 TC-32 siFLI1, rep 2 TC-32 siFLI1,
- GSM7780326 TC-32 siFLI1, rep 3 TC-32 siFLI1,
- GSM7780327 TC-71 siNEG, rep 1 TC-71 siNEG,
- GSM7780328 TC-71 siNEG, rep 2 TC-71 siNEG,
- GSM7780329 TC-71 siNEG, rep 3 TC-71 siNEG,
- GSM7780330 TC-71 siFLI1, rep 1 TC-71 siFLI1,
- GSM7780331 TC-71 siFLI1, rep 2 TC-71 siFLI1,
- GSM7780332 TC-71 siFLI1, rep 3 TC-71 siFLI1,
- GSM7780333 A673 siNEG, rep 1 A673 siNEG,
- GSM7780334 A673 siNEG, rep 2 A673 siNEG,
- GSM7780335 A673 siNEG, rep 3 A673 siNEG,
- GSM7780336 A673 siFLI1, rep 1 A673 siFLI1,
- GSM7780337 A673 siFLI1, rep 2 A673 siFLI1,
- GSM7780338 A673 siFLI1, rep 3 A673 siFLI1,
- GSM7782750 TC-32 WT, A, IgG, rep 1 TC-32 WT, A, IgG,
- GSM7782751 TC-32 WT, A, IgG, rep 2 TC-32 WT, A, IgG,
+ 23 more — browse all 63 samples with per-sample file links →
- GSE243171 EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (ChIP-seq) 22 samples shares ewsr1, ets1, fli1, oncoprotein, protein
- GSE243183 EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (RNA-seq) 18 samples shares ewsr1, ets1, fli1, oncoprotein, protein
- GSE243277 EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (CUT&RUN) 14 samples shares ewsr1, ets1, fli1, oncoprotein, protein
- GSE243279 EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (RNA-seq) 9 samples shares ewsr1, ets1, fli1, oncoprotein, protein
- GSE290895 Rewiring the fusion oncoprotein EWSR1::FLI1 in Ewing scarcoma with bivalent small molecules [RNA-Seq] 54 samples shares ewsr1, fli1, oncoprotein, protein
- GSE290894 Rewiring the fusion oncoprotein EWSR1::FLI1 in Ewing scarcoma with bivalent small molecules [ChIP-Seq] 24 samples shares ewsr1, fli1, oncoprotein, protein
- GSE270570 Endogenous degron alleles enable tunable control of EWSR1-FLI1 oncoprotein expression 7 samples shares ewsr1, fli1, oncoprotein, protein
- GSE290893 Rewiring the fusion oncoprotein EWSR1::FLI1 in Ewing scarcoma with bivalent small molecules [ATAC-seq] 4 samples shares ewsr1, fli1, oncoprotein, protein
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.