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BRD4 inhibitor GNE987 exerts anti-cancer effects in Osteosarcoma

GSE243673 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2024/08/08 Platform GPL28038
Summary
GNE987 is a newly developed von Hippel-Lindau tumor suppressor (VHL)-based pan-BET-targeting PROTAC, which can bind to the target proteins (BET proteins, including BRD2, BRD3, and BRD4) and recruit them to the ubiquitin/proteasome system for selective degradation. In the our study, ChIP-Seq analysis was performed to explore the effect of GNE987 on osteosarcoma cells.
Published in
The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma
Wu D, Yin H, Yang C et al. · BMC cancer 2024 · PMID 39090568 · doi:10.1186/s12885-024-12691-y
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Also filed as BioProject PRJNA1019364 and SRA study SRP462059. Searching any of these in the dataset finder brings you back here.

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