BRD4 Regulates Gemcitabine Efficacy by Modulating Autophagy Activity in Osteosarcoma Cells [Cell lines]
RNA-seq (gene expression) · human · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- OsteosarcomaThis series is part of our curated briefing on it.
- Samples
- 10 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255956_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1077299 and SRA study SRP490026. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 10 more — browse all 10 samples with per-sample file links →
- GSE255957 BRD4 Regulates Gemcitabine Efficacy by Modulating Autophagy Activity in Osteosarcoma Cells [Patient samples] 6 samples same disease briefing · shares brd4, osteosarcoma, gemcitabine, modulating, autophagy, efficacy, activity
- GSE218036 Transcriptome analysis of osteosarcoma cell lines treated with FDA-approved drugs 18 samples same disease briefing · shares osteosarcoma, lines
- GSE243673 BRD4 inhibitor GNE987 exerts anti-cancer effects in Osteosarcoma 9 samples same disease briefing · shares brd4, osteosarcoma
- GSE324043 Celastrol induces autophagy and apoptosis of human osteosarcoma cells via downregulation PI3K/Akt/mTOR signaling pathway 6 samples same disease briefing · shares osteosarcoma, autophagy
- GSE42352 Genome-wide gene expression profiling of mesenchymal stem cells, osteosarcoma cells, and osteosarcoma cell lines. 118 samples same disease briefing · shares osteosarcoma, lines
- GSE259286 In vitro modeling of nutritional and mitochondrial-targeted therapies for osteosarcoma 98 samples same disease briefing · shares osteosarcoma
- GSE253548 The whole transcriptome analysis using FFPE and fresh tissue samples identifies the molecular fingerprint of osteosarcoma 90 samples same disease briefing · shares osteosarcoma
- GSE152048 Single cell analysis of osteosarcoma tissues 76 samples same disease briefing · shares osteosarcoma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.