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Identification of XD23 as a potent inhibitor of osteosarcoma via downregulation of DKK1 and activation of the WNT/β-Catenin pathway

GSE262143 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/08/22 Platform GPL24676
Summary
Osteosarcoma, the most prevalent malignant bone tumor, is notorious for its aggressive growth and invasiveness. The highly mutable genome of osteosarcoma has made identifying a key oncogene challenging, hindering the development of targeted treatments. Our study validates the effectiveness of XD23, an anti-cancer agent we previously identified, in curbing osteosarcoma proliferation, metastasis, EMT differentiation, and bone destruction and promoting osteosarcoma apoptosis.
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Also filed as BioProject PRJNA1090468 and SRA study SRP496998. Searching any of these in the dataset finder brings you back here.

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