GEO series
Dietary folate and cofactors accelerate age-dependent p16 epimutation to promote intestinal tumorigenesis
GSE243762
Mus musculus
Expression profiling by high throughput sequencing
13 samples
2024/08/19
GPL24247
Summary
We use a mouse model of age-dependent p16 epimutation, in which the p16 gene activity is directly controlled by promoter DNA methylation. We show p16 epimutation is modulated by folate and cofactors in dietary supplementation, which leads to increased colon cancer risk. Importantly, our findings provide functional evidence concerning the safety of folate fortification in the general population.
Download
NCBI GEO page ↗
Paper (PMID 38259096) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
mouse RNA-seq datasets →
Similar datasets
- GSE292862 Modelling mouse embryogenesis from chemically induced totipotent stem cells 22 samples
- GSE185862 A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation 95 samples
- GSE334940 Tissue nanotransfection-mediated induction of neurogenic programs promotes myoprotective responses in denervated skeletal muscle 15 samples
- GSE304862 Semaglutide and exercise synergy in obesity: preserving muscle mass and uncovering organ crosstalk 209 samples
- GSE343043 Disease context dictates the cellular targets of IL-17 in inflammatory skin disease 29 samples
- GSE341948 Multi-tissue transcriptomic landscape reveals synergistic mechanisms of exercise and GLP-1 agonist in ameliorating diabetic phenotypes in db/db mice 12 samples
- GSE293315 MRPGRX2 Antagonist Treatment Prevents Inflammation and Disease in a Mouse Model of Atopic Dermatitis Dataset 2 35 samples
- GSE321707 Characterization of TLR signaling in Ticam2-/- macrophages 30 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.