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Effect of polyIC administration on gene expression in decidual NK cells of E13.5 mice

GSE244115 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/08/01 Platform GPL24247
Summary
Previous research indicate that maternal immune activation (MIA) correlated with increased frequency of autism spectrum disorder (ASD) in offspring. Our data sugests that maternal NK cells facilitate MIA-induced neurodevelopment and behavioral disorders. To determine how aberrant maternal NK cells instruct the developmental trajectory of the fetal brain environment, we evaluated the DEGs of decidua NK cells from dams triggered with polyIC or saline control.
Published in
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B
Bian Q, Chen Y, Zhang J et al. · Immunity 2025 · PMID 40381623 · doi:10.1016/j.immuni.2025.04.028
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Also filed as BioProject PRJNA1021252 and SRA study SRP463297. Searching any of these in the dataset finder brings you back here.

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