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SYISL affects fetal mice muscle fiber number by regulating maternal intestinal microbiota and their metabolites

GSE244822 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/19 Platform GPL13112
Summary
The formation of embryonic muscle fibers during the prenatal period determines the number of muscle fibers after birth. Our previous studies showed that SYISL gene knockout (KO) mice significantly increased the number of total muscle fibers, but the underlying mechanism remains unclear. In this study, we found that the development of embryonic muscle fibers was significantly influenced by the interaction between host SYISL genotype and maternal gut microbiota. SYISL KO alters the composition of the female mice maternal gut microbiota, significantly increases the relative abundance of Prevotella (P<0.05). Fecal microbiota transplantation (FMT) experiments indicated that fecal suspension from KO female mice significantly increased the number of offspring muscle fibers. Our study provides the new evidence for the interaction between maternal single gene and gut microbiota on the embryonic muscle development of the offspring.
Published in
SYISL Knockout Promotes Embryonic Muscle Development of Offspring by Modulating Maternal Gut Microbiota and Fetal Myogenic Cell Dynamics
Zuo H, Jiang W, Gao J et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 39680624 · doi:10.1002/advs.202410953
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Also filed as BioProject PRJNA1024964 and SRA study SRP464898. Searching any of these in the dataset finder brings you back here.

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