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Histone Modification in Cerebral Arteriovenous Malformation

GSE245171 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/05/30 Platform GPL21493
Summary
Cerebral arteriovenous malformations (AVMs) are the most common vascular malformations worldwide and the leading cause of hemorrhagic strokes that result in crippling neurological deficits. Here, using newly generated mouse model, we discovered that genome-wide ocuppancy of H4K8ac and H3K27me3 decreased in mouse cerebral AVMs.
Published in
Inhibition of endothelial histone deacetylase 2 shifts endothelial-mesenchymal transitions in cerebral arteriovenous malformation models
Zhao Y, Wu X, Yang Y et al. · The Journal of clinical investigation 2024 · PMID 38781032 · doi:10.1172/JCI176758
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Also filed as BioProject PRJNA1027297 and SRA study SRP466091. Searching any of these in the dataset finder brings you back here.

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