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Regulation of muscle mass by Thrombospondin-1

GSE245663 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/04/18 Platform GPL21626
Summary
Loss of muscle mass is a pathological driver in both chronic illness and aging. We have discovered that skeletal muscle specific thrombospondin-1 (Thbs1) transgenic mice have profound muscle atrophy with age-dependent decreases in exercise capacity and premature lethality. Here, we compared the transcriptional profiles of skeletal muscle from control non-transgenic mice with those overexpressing Thbs1 in order to elucidate the transcriptional changes underlying the observed effects on skeletal muscle mass. The overall purpose was to identify new, effective targets to combat muscle atrophy and sarcopenia.
Published in
Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
Vanhoutte D, Schips TG, Minerath RA et al. · Cell reports 2024 · PMID 38678560 · doi:10.1016/j.celrep.2024.114149
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Direct links to NCBI, no account and no request form: the whole study as GSE245663_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1029530 and SRA study SRP467040. Searching any of these in the dataset finder brings you back here.

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