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0.1 Terahertz irradiation alleviates rheumatoid arthritis and exerts immunomodulatory effects in CIA mice

GSE246029 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/06/20 Platform GPL24247
Summary
This study investigated the systemic effects of 0.1 THz irradiation on the inflammatory status of rheumatoid arthritis (RA) in the collagen-induced arthritis (CIA) mouse model. It was found that THz irradiation apparently alleviated the symptoms of arthritis in CIA mice, reducing the joint swelling, mitigating the tissue damage and relieving the expression of pro-inflammatory factors (TNF-, IL-6, RANKL and MMPs) in the swollen joint of the CIA mice. Moreover, the reduction of serum inflammatory cytokines levels together with the reduced CD4+ T cell count and the recovered percentage of regulatory T cells (Treg) indicated that THz irradiation exerted a systemic immunoregulatory activity in CIA mice. The blood leukocyte mRNA-seq GO analysis also enriched several biological processes including the differentiation and adhesion of leukocytes, lymphocyte differentiation and T cell activation, providing additional supporting evidence for the immunoregulatory effects of THz.
Published in
Anti-Inflammatory and Immunomodulatory Effects of 0.1 Sub-Terahertz Irradiation in Collagen-Induced Arthritis Mice
Zhang Q, Shang S, Li X et al. · International journal of molecular sciences 2024 · PMID 38892148 · doi:10.3390/ijms25115963
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Also filed as BioProject PRJNA1031161 and SRA study SRP468033. Searching any of these in the dataset finder brings you back here.

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