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RNA-Seq analysis SIRT6 knockdown effect on vascular smooth muscle cells

GSE246209 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/11 Platform GPL24247
Summary
Vascular smooth muscle cells (VSMCs) phenotype switch has been thought to be critical to the development of thoracic aneurysm/dissection. To investigate the function SIRT6 in the regulation of VSMCs phenotype switch, we established mouse vascular smooth muscle cells in which each target gene has been knocked down by siRNA.
Published in
SGK1-Mediated Vascular Smooth Muscle Cell Phenotypic Transformation Promotes Thoracic Aortic Dissection Progression
Leng S, Li H, Zhang P et al. · Arteriosclerosis, thrombosis, and vascular biology 2025 · PMID 39633576 · doi:10.1161/ATVBAHA.124.321421
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Also filed as BioProject PRJNA1032046 and SRA study SRP468332. Searching any of these in the dataset finder brings you back here.

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