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Comparative bulk RNAseq analysis of Control and Ctnnb1-deficient CXCL12+ apical papilla cells.

GSE248398 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/05/21 Platform GPL21626
Summary
Lack of Ctnnb1 in CXCL12+ apical papilla cells causes a cell fate shift and fail to differentiate into root forming cells such as odontoblasts or cementoblasts. Here, we set out to reveal the transcriptome change induced by Ctnnb1 deficiency in CXCL12+ apical papilla cells
Published in
Wnt-directed CXCL12-expressing apical papilla progenitor cells drive tooth root formation
Nagata M, Gadhvi GT, Komori T et al. · Nature communications 2025 · PMID 40595672 · doi:10.1038/s41467-025-61048-x
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Also filed as BioProject PRJNA1043677 and SRA study SRP473377. Searching any of these in the dataset finder brings you back here.

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