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Analysis of differential genes in osteogenic induction of alveolar bone derived MSCs under TNFα-induced inflammation in Ccrl2-KO mice and WT mice.

GSE248831 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/31 Platform GPL24247
Summary
In order to explore the effect of Ccrl2 knockout on the osteogenic differentiation of MSCs under inflammatory conditions, MSCs derived from the alveolar bones of Ccrl2-KO mice and WT mice were extracted, and total cellular RNA was extracted after 2 days of osteogenic induction under TNFα-induced inflammation, and carried out RNA-Seq to identify the potential mechanism by which Ccrl2 regulates osteogenic-related signals.
Published in
Leptin receptor (+) stromal cells respond to periodontitis and attenuate alveolar bone repair via CCRL2-mediated Wnt inhibition
Chen Y, Weng Y, Huang J et al. · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 · PMID 38477792 · doi:10.1093/jbmr/zjae036
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Also filed as BioProject PRJNA1046081 and SRA study SRP474724. Searching any of these in the dataset finder brings you back here.

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