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Glucocorticoid Receptor cistromic reprogramming by caloric restriction and corticosterone treatments.

GSE248865 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/11/04 Platform GPL24247
Summary
In order to examine the impact of two separate corticosterone surges on liver physiology, we conducted genome-wide mapping of GR binding profiles at 6 pm (ZT12) through ChIP-sequencing. This was done using liver samples from mice subjected to either short-term caloric restriction or corticosterone injections. Our findings reveal that both interventions yield unique binding profiles.
Published in
Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms
Makris K, Fonda V, Ramadhani FF et al. · Nature communications 2025 · PMID 41381594 · doi:10.1038/s41467-025-67228-z
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Also filed as BioProject PRJNA1046134 and SRA study SRP474710. Searching any of these in the dataset finder brings you back here.

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