Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communications
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 4 × BAT BKO vs 3 × BAT WT vs 3 × GAS BKO vs 3 × GAS WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communicationThe Journal of clinical investigation · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249030_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1047047 and SRA study SRP475245. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 13 samples.
How we read this: 4 replicated groups read from 13 sample titles; they account for 13 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7925402 BAT BKO rep1 BAT BKO
- GSM7925403 BAT BKO rep2 BAT BKO
- GSM7925404 BAT BKO rep3 BAT BKO
- GSM7925405 BAT BKO rep4 BAT BKO
- GSM7925406 BAT WT rep1 BAT WT
- GSM7925407 BAT WT rep2 BAT WT
- GSM7925408 BAT WT rep3 BAT WT
- GSM7925409 GAS BKO rep1 GAS BKO
- GSM7925410 GAS BKO rep2 GAS BKO
- GSM7925411 GAS BKO rep3 GAS BKO
- GSM7925412 GAS WT rep1 GAS WT
- GSM7925413 GAS WT rep2 GAS WT
- GSM7925414 GAS WT rep3 GAS WT
- GSE281608 CREBH Regulates Mitochondrial Unfolded Protein Response to Maintain Energy Homeostasis 6 samples shares homeostasis, energy
- GSE279884 Perimenopausal State Oestradiol to Progesterone Imbalance Drives Alzheimer’s Risk via ERRα Dysregulation and Energy Dyshomeostasis [VCD_Cycle14] 11 samples shares homeostasis, energy
- GSE218178 Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance 183 samples shares microenvironment
- GSE240578 MAD2-dependent insulin receptor endocytosis regulates metabolic homeostasis 20 samples shares homeostasis
- GSE218173 Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance [acid] 150 samples shares microenvironment
- GSE259380 TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody induces tumor regression through profound tumor microenvironment remodeling and strong antitumor adaptive immune response [RNA-seq] 149 samples shares microenvironment
- GSE305266 The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing 90 samples shares microenvironment
- GSE330351 Ferritin-mediated iron homeostasis regulates fibroblast activation and shapes post-infarction cardiac remodeling 9 samples shares homeostasis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.