Amphiregulin-producing T helper 2 cells have critical role in esophageal fibrosis of EoE
Single-cell RNA-seq · human · 12 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 2 × mouse_EoE_Control_CD45 vs 2 × mouse_EoE_HDM_CD45 vs 2 × human_EoE_posi_CD45p vs 2 × human_Control_esophagitis_CD45pGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Amphiregulin-producing T(H)2 cells facilitate esophageal fibrosis of eosinophilic esophagitisThe journal of allergy and clinical immunology. Global · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249276_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1048421 and SRA study SRP475793. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7932752 mouse_EoE_Control_CD45_1 mouse_EoE_Control_CD45
- GSM7932753 mouse_EoE_Control_CD45_2 mouse_EoE_Control_CD45
- GSM7932754 mouse_EoE_Control_CD4
- GSM7932755 mouse_EoE_HDM_CD45_1 mouse_EoE_HDM_CD45
- GSM7932756 mouse_EoE_HDM_CD45_2 mouse_EoE_HDM_CD45
- GSM7932757 mouse_EoE_HDM_CD4
- GSM7932758 human_EoE_posi_CD45n
- GSM7932759 human_EoE_posi_CD45p_1 human_EoE_posi_CD45p
- GSM7932760 human_EoE_posi_CD45p_2 human_EoE_posi_CD45p
- GSM7932761 human_Control_esophagitis_posi_CD45
- GSM7932762 human_Control_esophagitis_CD45p_1 human_Control_esophagit…
- GSM7932763 human_Control_esophagitis_CD45p_2 human_Control_esophagit…
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.