Identification of Ephrin type-B receptor 4 (EphB4) as a critical mediator of tissue fibrosis
RNA-seq (gene expression) · human · 45 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 45 samples: 37 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Identification of Ephrin type-B receptor 4 as a critical mediator of tissue fibrosisJCI insight · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273468_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1141969 and SRA study SRP378906. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 45 sample titles: 37 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6215489 4C1233F
- GSM6215490 4C1242F
- GSM6215491 4C1271M
- GSM6215492 4C1272M
- GSM6215493 4C1241M
- GSM6215494 4C1154F
- GSM6215495 4C1177F
- GSM6215496 4C1181F
- GSM6215497 4C1243M
- GSM6215498 4C1241F
- GSM6215499 4C1164M
- GSM6215500 4C1195F
- GSM6215501 4C1231M
- GSM6215502 4C1242M
- GSM6215503 4C1165M
- GSM6215504 4C1172F
- GSM6215505 4C1194F
- GSM6215506 IPF1C
- GSM6215507 IPF1I
- GSM6215508 IPF2C
- GSM6215509 IPF2I
- GSM6215510 IPF3C
- GSM6215511 IPF3I
- GSM6215512 IPF4C
- GSM6215513 IPF4I
- GSM8427019 HLF1_Vehicle
- GSM8427020 HLF2_Vehicle
- GSM8427021 HLF3_Vehicle
- GSM8427022 HLF5_Vehicle
- GSM8427023 HLF1_NVP-BHG712
- GSM8427024 HLF2_NVP-BHG712
- GSM8427025 HLF3_NVP-BHG712
- GSM8427026 HLF5_NVP-BHG712
- GSM8428898 Mouselungs_PBS_Vehicle_1
- GSM8428899 Mouselungs_PBS_Vehicle_2
- GSM8428900 Mouselungs_PBS_Vehicle_3
- GSM8428901 Mouselungs_PBS_NVP-BHG712_1
- GSM8428902 Mouselungs_PBS_NVP-BHG712_2
- GSM8428903 Mouselungs_PBS_NVP-BHG712_3
- GSM8428907 Mouselungs_Bleo_NVP-BHG712_1
+ 5 more — browse all 45 samples with per-sample file links →
- GSE188242 Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27–Driven Itch Pathway 24 samples shares receptor, mediator
- GSE249276 Amphiregulin-producing T helper 2 cells have critical role in esophageal fibrosis of EoE 12 samples shares critical, fibrosis
- GSE275942 Estrogen Receptor 1 Signaling in Hepatic Stellate Cells Designates Resistance to Liver Fibrosis 11 samples shares receptor, fibrosis
- GSE294247 The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing 110 samples shares critical
- GSE341321 Vitamin B2 Sensing by the Nuclear Receptor AhR Reprograms Hepatic Metabolism [RNA-Seq] 100 samples shares receptor
- GSE250280 Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD 39 samples shares receptor
- GSE280356 Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models 26 samples shares receptor
- GSE254156 The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumor suppression 25 samples shares receptor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.