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The effects of JAK inhibition on SARS-CoV-2-induced kidney injury

GSE249303 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/04/18 Platform GPL24247
Summary
Patients often present with kidney injury in COVID-19. Although severe COVID-19 cases are treated with baricitinib, a JAK inhibitor, the effects of baricitinib on the kidneys in COVID-19 are unclear. The authors examined the pharmacological effects of baricitinib on kidney injury using an in vivo murine COVID-19 model.
Published in
JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice
Sakai H, Kamuro H, Tokunoh N et al. · American journal of physiology. Renal physiology 2024 · PMID 38634132 · doi:10.1152/ajprenal.00011.2024
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Also filed as BioProject PRJNA1048483 and SRA study SRP475768. Searching any of these in the dataset finder brings you back here.

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