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Effect of inhibition of Phospholipase D on gene expression during spinal cord injury

GSE249615 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/03/06 Platform GPL24247
Summary
Phospholipase D (PLD), a critical lipid signaling molecule, is known to be involved in various physiological processes. Despite this knowledge, the specific role of PLD in spinal cord injury remains unclear. In this study, we constructed mouse models of SCI and administered PLD inhibitor(FIPI) treatment to investigate the efficacy of PLD. Transcriptome sequencing analysis implicated inhibition of PLD altered gene expression in the inflammation regulation.
Published in
Inhibition of phospholipase D promotes neurological function recovery and reduces neuroinflammation after spinal cord injury in mice
Ke H, Bai F, Li Z et al. · Frontiers in cellular neuroscience 2024 · PMID 38572075 · doi:10.3389/fncel.2024.1352630
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Also filed as BioProject PRJNA1049821 and SRA study SRP476434. Searching any of these in the dataset finder brings you back here.

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