Transcriptional profiles of tumor-draining lymph node resident CD11c+ cells in wildtype versus APOE-KO mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 × wt CD11c+, sample vs 6 × KO CD11c+, sampleGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunityThe Journal of experimental medicine · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE249704_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1050216 and SRA study SRP476630. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7960580 wt CD11c+, sample 01 wt CD11c+, sample
- GSM7960582 wt CD11c+, sample 02 wt CD11c+, sample
- GSM7960583 wt CD11c+, sample 03 wt CD11c+, sample
- GSM7960584 wt CD11c+, sample 04 wt CD11c+, sample
- GSM7960585 wt CD11c+, sample 05 wt CD11c+, sample
- GSM7960588 wt CD11c+, sample 06 wt CD11c+, sample
- GSM7960589 KO CD11c+, sample 07 KO CD11c+, sample
- GSM7960591 KO CD11c+, sample 08 KO CD11c+, sample
- GSM7960592 KO CD11c+, sample 09 KO CD11c+, sample
- GSM7960594 KO CD11c+, sample 10 KO CD11c+, sample
- GSM7960596 KO CD11c+, sample 11 KO CD11c+, sample
- GSM7960597 KO CD11c+, sample 12 KO CD11c+, sample
- GSE252068 Gene expression profiles of N-propargylglycine (N-PPG) treatment on wildtype and Huntington's mice 23 samples shares profiles, wildtype
- GSE202232 Comparing transcriptional profiles of type 2 innate lymphoid cells from WT and Rag1 knockout mice 12 samples shares profiles, lymph
- GSE267535 TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer 10 samples shares tumor-draining, lymph
- GSE291836 Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node 19 samples shares tumor-draining, lymph
- GSE276029 Transcriptional profiling of cDC2 subsets in IFNAR∆CD11c mice treated with allergens 24 samples shares cd11c
- GSE129746 RNA-seq data of Ly6Chigh CD11c+ MHC-II+ and Ly6C low cells FACS-sorted from Mock-LLC and SULT2B1b-LLC tumors 15 samples shares cd11c
- GSE243160 Transcriptomic differences in RXRαβ-deficient and WT alveolar macrophages using the CD11c-Cre+ mouse model (RNA-Seq) 11 samples shares cd11c
- GSE249963 Bulk RNA seq of sorted CD11c cells from lungs of uninfected and Mtb infected wild type mice. 10 samples shares cd11c
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.