Gene expression profiles of N-propargylglycine (N-PPG) treatment on wildtype and Huntington's mice
RNA-seq (gene expression) · mouse · 23 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 23 samples: 16 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Brain transcriptomic, metabolic and mitohormesis properties associated with N-propargylglycine treatment: A prevention strategy against neurodegenerationBrain research · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252068_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1057256 and SRA study SRP480178. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 23 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7993261 Brain, Wildtype, no N-PPG, 1W
- GSM7993262 Brain, Wildtype, no N-PPG, 2W
- GSM7993263 Brain, Wildtype, no N-PPG, 3W
- GSM7993264 Brain, Wildtype, no N-PPG, 4W
- GSM7993265 Brain, Wildtype, N-PPG, 5WT
- GSM7993266 Brain, Wildtype, N-PPG, 6WT
- GSM7993267 Brain, Wildtype, N-PPG, 7WT
- GSM7993268 Brain, Wildtype, N-PPG, 8WT
- GSM7993269 Brain, Wildtype, N-PPG, 9WT
- GSM7993270 Brain, Huntington's, no N-PPG, 10H
- GSM7993271 Brain, Huntington's, no N-PPG, 11H
- GSM7993272 Brain, Huntington's, no N-PPG, 12H
- GSM7993273 Brain, Huntington's, N-PPG, 13HT
- GSM7993274 Brain, Huntington's, N-PPG, 15HT
- GSM7993275 Brain, Wildtype, N-PPG, 57
- GSM7993276 Brain, Wildtype, no N-PPG, 58
- GSM7993277 Brain, Wildtype, no N-PPG, 59
- GSM7993278 Brain, Wildtype, no N-PPG, 64
- GSM7993279 Brain, Wildtype, N-PPG, 67
- GSM7993280 Brain, Wildtype, no N-PPG, 68
- GSM7993281 Brain, Wildtype, no N-PPG, 69
- GSM7993282 Brain, Wildtype, N-PPG, 70
- GSM7993283 Brain, Wildtype, N-PPG, 71
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.