NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 40 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 40 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNAMolecular cell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE250430_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1054048 and SRA study SRP478241. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 22 samples.
How we read this: 10 replicated groups read from 40 sample titles; they account for 22 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7976834 1_4T1_WT_1_S1
- GSM7976835 2_4T1_WT_2_S2
- GSM7976836 3_4T1_WT_3_S3
- GSM7976837 4_Nat10_KO_c19_1_S4
- GSM7976838 5_Nat10_KO_c19_2_S5
- GSM7976839 6_Nat10_KO_c19_3_S6
- GSM7976840 7_Nat10_KO_c43_1_S7
- GSM7976841 8_Nat10_KO_c43_2_S8
- GSM7976842 9_Nat10_KO_c43_3_S9
- GSM7979052 H3K27ac_WT biol rep1 H3K27ac_WT biol
- GSM7979053 H3K27ac_WT biol rep2 H3K27ac_WT biol
- GSM7979054 H3K27ac_KO biol rep1 H3K27ac_KO biol
- GSM7979055 H3K27ac_KO biol rep2 H3K27ac_KO biol
- GSM7979056 H4K20ac_WT biol rep1 H4K20ac_WT biol
- GSM7979057 H4K20ac_WT biol rep2 H4K20ac_WT biol
- GSM7979058 H4K20ac_KO biol rep1 H4K20ac_KO biol
- GSM7979059 H4K20ac_KO biol rep2 H4K20ac_KO biol
- GSM7979060 H3K27me3_WT biol rep1 H3K27me3_WT biol
- GSM7979061 H3K27me3_WT biol rep2 H3K27me3_WT biol
- GSM7979062 H3K27me3_KO biol rep1 H3K27me3_KO biol
- GSM7979063 H3K27me3_KO biol rep2 H3K27me3_KO biol
- GSM7979068 Input_WT biol rep1 Input_WT biol
- GSM7979069 Input_WT biol rep2 Input_WT biol
- GSM7979070 Input_KO biol rep1 Input_KO biol
- GSM7979071 Input_KO biol rep2 Input_KO biol
- GSM7979072 Nat10
- GSM7979073 Brd4-pan
- GSM7979074 Brd4 short isoform-V5 tagged
- GSM7979075 Rrp1b endogenous
- GSM7979076 Rrp1b-HA tagged
- GSM7979077 Sipa1
- GSM7979078 Input
- GSM8599425 p300-RNA-ChIP-WT biol rep1 p300-RNA-ChIP-WT biol
- GSM8599426 p300-RNA-ChIP-WT biol rep2 p300-RNA-ChIP-WT biol
- GSM8599427 p300-RNA-ChIP-WT biol rep3 p300-RNA-ChIP-WT biol
- GSM8599428 p300-RNA-ChIP-Nat10 KO biol rep1 p300-RNA-ChIP-Nat10 KO …
- GSM8599429 p300-RNA-ChIP-Nat10 KO biol rep2 p300-RNA-ChIP-Nat10 KO …
- GSM8599430 p300-RNA-ChIP-Nat10 KO biol rep3 p300-RNA-ChIP-Nat10 KO …
- GSM8599431 Input-WT-pool
- GSM8599432 Input-Nat10 KO-pool
- GSE250428 NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA [ChIP-seq] 23 samples shares nat10, p300, cbp, chromatin-associated, metastasis, modulating, promotes, activity
- GSE250284 NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA [RNA-seq] 9 samples shares nat10, p300, cbp, chromatin-associated, metastasis, modulating, promotes, activity
- GSE337703 p300/CBP inhibition promotes apoptosis in mouse embryos by impairing H1K75ac-mediated DNA repair from the 4-cell to blastocyst stage 8 samples shares p300, cbp, promotes
- GSE280521 p300/CBP-catalyzed acetylation safeguards minor zygotic genome activation via activating DUX [ChIPseq_ATAC-seq_Stacc-seq] 50 samples shares p300, cbp
- GSE280522 p300/CBP-catalyzed acetylation safeguards minor zygotic genome activation via activating DUX [RNA-Seq] 24 samples shares p300, cbp
- GSE309163 P300/CBP inhibition with gilteritinib and venetoclax targets leukemia stem cells in epigenetic mutant AML [ChIP-Seq] 16 samples shares p300, cbp
- GSE264627 CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC 16 samples shares p300, cbp
- GSE309162 P300/CBP inhibition with gilteritinib and venetoclax targets leukemia stem cells in epigenetic mutant AML [RNA-Seq] 12 samples shares p300, cbp
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.