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The effect of myeloid STING knockout after tumor formation on gene expression in AOM/DSS-induced CAC mice

GSE252099 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/14 Platform GPL24247
Summary
Myeloid-derived STING has been recognized to play a vital role in mediating the development of colitis-associated carcinoma (CAC). We here report that myeloid-specific knockout of STING after tumor formation enhanced tumor growth by modifying the tumor microenvironment to a more immunologically inactive state. Pathways related to antigen presentation, macrophage and DC activation, T cell chemotaxis and activation, T cell-mediated cytotoxicity and other immune responses to tumor cells were all inhibited by lateral myeloid STING kncckout after tumor formation.
Published in
Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitis
Cai Y, Li S, Yang Y et al. · Theranostics 2024 · PMID 39113810 · doi:10.7150/thno.96184
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Also filed as BioProject PRJNA1057800 and SRA study SRP480281. Searching any of these in the dataset finder brings you back here.

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